UBXN2B: A Non-Code RNA Molecule Regulating Stem Cell Proliferation

Target Name: UBXN2B

NCBI ID: G137886

UBXN2B: A Non-Code RNA Molecule Regulating Stem Cell Proliferation

UBXN2B, also known as UBXN2B protein, is a protein that is located in the UBX gene on chromosome 16. It is a non-coding RNA molecule that plays a role in the regulation of gene expression. UBXN2B is expressed in almost all human tissues and is highly conserved across species.

UBXN2B is a key regulator of stem cell proliferation and differentiation. It has also been shown to play a role in the regulation of cell cycle progression, and is required for the maintenance of stem cell self-renewal. UBXN2B has also been shown to play a role in the regulation of angiogenesis, the formation of new blood vessels, and the regulation of inflammation.

UBXN2B is also a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Several studies have shown that UBXN2B is overexpressed in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. Overexpression of UBXN2B has has been shown to promote the growth and survival of cancer cells, and may contribute to the development and progression of these diseases.

In addition to its potential as a drug target, UBXN2B is also a potential biomarker for several diseases. Its overexpression in cancer cells makes it a promising marker for cancer diagnosis and monitoring. It has also been shown to be overexpressed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and may serve as a potential biomarker for these conditions.

UBXN2B is also a potential target for small molecule inhibitors. Its overexpression in cancer cells makes it a promising target for small molecule inhibitors that can be used to treat cancer. Several studies have shown that UBXN2B is sensitive to small molecule inhibitors, and that these inhibitors can be effective in inhibiting the growth and survival of cancer cells.

In conclusion, UBXN2B is a non-coding RNA molecule that is expressed in almost all human tissues. It plays a key role in the regulation of stem cell proliferation and differentiation, and is required for the maintenance of stem cell self-renewal. UBXN2B is also a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. It is also a potential biomarker for these conditions, and is sensitive to small molecule inhibitors. Further research is needed to fully understand the role of UBXN2B in disease progression and the development of new treatments.

Protein Name: UBX Domain Protein 2B

Functions: Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807)

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