Unlocking The Potential Therapeutic Applications of UBE3D (G90025)

Target Name: UBE3D

NCBI ID: G90025

Unlocking The Potential Therapeutic Applications of UBE3D

Ubiquitin (Ub) is a protein that plays a crucial role in regulating various cellular processes in the cell. One of the most well-known functions of Ubqi is its role in protein degradation, which is a critical process for maintaining cellular homeostasis and removing damaged or unnecessary proteins. Ubqi also plays a key role in the regulation of cell signaling pathways, and is involved in the delivery of several signaling molecules to their respective targets.

The E3 ubiquitin transferase (E3-UT) is a protein that adds the Ubqi tail to target proteins. This process is critical for the regulation of protein degradation and for the delivery of signaling molecules to their targets. One of the unique features of the E3 -UT is its ability to transfer the Ubqi tail to a specific target protein, which is known as HECT-type Ubqi (HECT-Ub).

HECT-Ub is a 21 kDa protein that is expressed in most tissues of the body. It is composed of two distinct subunits, alpha and beta, which are held together by a disulfide bond. The alpha subunit has a catalytic active site and is responsible for the transfer of the Ubqi tail to the target protein. The beta subunit has a structural domain that interacts with the alpha subunit and is responsible for the regulation of the activity of the E3-UT.

The HECT-Ub protein is involved in the regulation of many different cellular processes, including cell signaling pathways, cell division, and DNA damage repair. It is also involved in the delivery of several signaling molecules to their targets, including the Ubqi-associated protein (UAP) and the DNA damage repair protein (DNMTAT).

UBE3D is a new drug target (or biomarker) that is being studied for its potential role in the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. UBE3D is a 3D protein that is composed of the E3-UT alpha subunit and the protein Ubc18.

UBE3D is expressed in most tissues of the body and is involved in the regulation of many different cellular processes, including cell signaling pathways, cell division, and DNA damage repair. It is also involved in the delivery of several signaling molecules to their targets, including the Ubqi-associated protein (UAP) and the DNA damage repair protein (DNMTAT).

One of the unique features of UBE3D is its ability to interact with the E3-UT alpha subunit and the Ubc18 protein. This interaction allows UBE3D to regulate the activity of the E3-UT and to modulate the activity of Ubc18. UBE3D has also been shown to interact with the protein component SIRT1, which is a NAD+-dependent protein that is involved in cellular stress response, DNA damage repair, and inflammation.

The ability of UBE3D to interact with the E3-UT alpha subunit and Ubc18 suggests that it may be a useful drug target or biomarker for the treatment of diseases that are characterized by the over-expression of these proteins. UBE3D is currently being tested in various cellular models and in animal models of disease, with the goal of identifying its potential therapeutic applications.

In addition to its potential therapeutic applications, UBE3D is also being studied for its potential as a biomarker for the diagnosis and monitoring of various diseases. For example, UBE3D has been shown to be overexpressed in several types of cancer, including breast cancer, lung cancer , and colorectal cancer. This suggests that UBE3D may be a useful biomarker for the detection and prognosis of these diseases.

Overall, UBE3D is a protein that is involved in

Protein Name: Ubiquitin Protein Ligase E3D

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

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