E2F8: A Protein Regulator of Cell Cycle and Cancer (G79733)

Target Name: E2F8

NCBI ID: G79733

E2F8: A Protein Regulator of Cell Cycle and Cancer

E2F8, also known as E2F-8, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of the cell cycle, a process that controls the growth, division, and progression of cells. E2F8 plays a crucial role in the regulation of the cell cycle, and it is involved in the development and progression of many diseases, including cancer.

In addition to its role in cell cycle regulation, E2F8 is also a potential drug target. Researchers have identified several potential drugs that can inhibit the activity of E2F8, and these drugs have been shown to have a variety of therapeutic effects, including the treatment of cancer.

One of the main targets of E2F8 is the protein p21, which is a key regulator of the cell cycle. E2F8 has been shown to interact with p21 and to regulate its activity. This interaction between E2F8 and p21 suggests that E2F8 may be a useful target for cancer treatments that target p21.

Another potential target of E2F8 is the protein p53, which is a key regulator of the DNA damage response. E2F8 has been shown to interact with p53 and to regulate its activity. This interaction between E2F8 and p53 suggests that E2F8 may be a useful target for cancer treatments that target p53.

In addition to its potential targets, E2F8 is also a potential biomarker for cancer. The expression of E2F8 has been shown to be elevated in a variety of cancer types, including breast, ovarian, and prostate cancers. This suggests that E2F8 may be a useful biomarker for the diagnosis and prognosis of cancer.

Overall, E2F8 is a protein that has important roles in the regulation of the cell cycle and in the development and progression of cancer. As such, it is a potential drug target and a potential biomarker for cancer. Further research is needed to fully understand the role of E2F8 in these processes and to develop effective treatments.

Protein Name: E2F Transcription Factor 8

Functions: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene

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