OBSCN: A Potential Drug Target for Muscle-Related Diseases (G84033)

Target Name: OBSCN

NCBI ID: G84033

OBSCN: A Potential Drug Target for Muscle-Related Diseases

Obscurin-myosin light chain kinase (OBSCN) is a protein that is expressed in muscle cells and is involved in the regulation of muscle contraction and relaxation. The OBSCN gene was identified as a potential drug target for muscle-related diseases, and research is currently being conducted to investigate its potential utility as a therapeutic intervention.

The OBSCN gene is located on chromosome 16 and encodes a protein that is composed of 255 amino acids. The protein has a molecular weight of 31.1 kDa and a calculated pI of 2.8. OBSCN is a light chain kinase, which means that it is involved in the regulation of protein function through the control of protein synthesis and degradation.

One of the key functions of OBSCN is its role in the regulation of muscle contractions. muscle contractions are essential for movement and maintaining posture, and OBSCN is involved in the regulation of the speed and strength of muscle contractions. OBSCN has been shown to play a role in the regulation of muscle force development and the termination of muscle contractions.

Another function of OBSCN is its role in the regulation of muscle relaxation. muscle relaxation is essential for muscle to return to its rest position after muscle contractions, and OBSCN is involved in the regulation of muscle relaxation. OBSCN has been shown to play a role in the regulation of muscle tone and the control of muscle relaxation.

OBSCN has also been shown to be involved in the regulation of muscle inflammation. muscle inflammation is an important aspect of muscle disease, and OBSCN is involved in the regulation of inflammation in muscle cells. OBSCN has been shown to play a role in the regulation of inflammation in muscle cells and has been shown to have anti-inflammatory effects.

In addition to its role in the regulation of muscle contractions and relaxation, OBSCN has also been shown to have potential therapeutic applications in other areas. For example, OBSCN has been shown to have potential anti-cancer effects by inhibiting the activity of cancer-promoting genes. OBSCN has also been shown to have potential anti-inflammatory effects by regulating the activity of inflammation-promoting genes.

Overall, OBSCN is a protein that is involved in the regulation of muscle contractions and relaxation, and has potential therapeutic applications in a variety of muscle-related diseases. Further research is needed to fully understand the role of OBSCN in muscle biology and to develop effective therapies based on OBSCN.

Protein Name: Obscurin, Cytoskeletal Calmodulin And Titin-interacting RhoGEF

Functions: Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662)

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