Target Name: OLFML3
NCBI ID: G56944
Other Name(s): Olfactomedin like 3, transcript variant 1 | Olfactomedin-like protein 3 (isoform 1) | OLF44 | OLFL3_HUMAN | Olfactomedin like 3, transcript variant 2 | olfactomedin, 44-kd | OLFML3 variant 1 | HNOEL-iso | Olfactomedin-like protein 3 (isoform 2) | hOLF44 | olfactomedin like 3 | OLFML3 variant 2 | Olfactomedin-like protein 3

OLFML3: Key Protein in Tight Junction and Pain Perception

Olfactomedin-like 3 (OLFML3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a member of the Olfactomedin gene family, which is characterized by the presence of a characteristic conserved domain called the Olfactomedin-like 3 (OLFML3) gene.

OLFML3 is a 21-kDa transmembrane protein that is expressed in the brain, heart, and kidneys. It is a key component of the tight junction, a specialized barrier that separates cells from the surrounding tissue. The tight junction helps to maintain the integrity of the body's tissues and is critical for various physiological processes, including the regulation of ion and solute transport.

OLFML3 has also been shown to play a role in the regulation of pain perception and neuroinflammation. In addition, it has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

As a drug target, OLFML3 is being investigated for its potential therapeutic applications in a variety of diseases. One of the main goals of research into OLFML3 is to understand its role in the development and progression of these diseases and to identify potential drug targets.

In addition to its potential therapeutic applications, OLFML3 also has significant implications for basic research into the regulation of cell biology processes. The Olfactomedin gene family has been shown to play a role in the regulation of various cellular processes, including cell adhesion, migration, and signaling.

Overall, OLFML3 is a protein that has significant implications for our understanding of the regulation of various physiological processes and has the potential to be a drug target for a variety of diseases. Further research is needed to fully understand its role in these processes and to identify its potential therapeutic applications.

Protein Name: Olfactomedin Like 3

Functions: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes

More Common Targets

OLIG1 | OLIG2 | OLIG3 | Oligosaccharyltransferase complex | OLMALINC | OLR1 | OMA1 | OMD | OMG | OMP | Oncostatin-M Receptor | ONECUT1 | ONECUT2 | ONECUT3 | OOEP | OOSP1 | OOSP2 | OPA1 | OPA1-AS1 | OPA3 | OPALIN | OPCML | OPHN1 | Opioid receptor | OPLAH | OPN1LW | OPN1MW | OPN1MW3 | OPN1SW | OPN3 | OPN4 | OPN5 | OPRD1 | OPRK1 | OPRL1 | OPRM1 | OPRPN | OPTC | OPTN | OR10A2 | OR10A3 | OR10A4 | OR10A5 | OR10A6 | OR10A7 | OR10AA1P | OR10AB1P | OR10AC1 | OR10AD1 | OR10AF1P | OR10AG1 | OR10AK1P | OR10C1 | OR10D1P | OR10D3 | OR10D4P | OR10G2 | OR10G3 | OR10G4 | OR10G7 | OR10G8 | OR10G9 | OR10H1 | OR10H2 | OR10H3 | OR10H4 | OR10H5 | OR10J1 | OR10J2P | OR10J3 | OR10J5 | OR10K1 | OR10K2 | OR10P1 | OR10Q1 | OR10R2 | OR10S1 | OR10T2 | OR10V1 | OR10W1 | OR10X1 | OR10Z1 | OR11A1 | OR11G2 | OR11H1 | OR11H12 | OR11H13P | OR11H2 | OR11H5P | OR11H6 | OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2