Target Name: OR11H1
NCBI ID: G81061
Other Name(s): Olfactory receptor family 11 subfamily H member 1 | Olfactory receptor, family 11, subfamily H, member 1 | OR22-1 | OTTHUMP00000028511 | seven transmembrane helix receptor | Seven transmembrane helix receptor | Olfactory receptor 11H1 | Olfactory receptor OR22-1 | olfactory receptor family 11 subfamily H member 1 | O11H1_HUMAN | OR11H12 | olfactory receptor OR22-1

OR11: Subfamily of T Cell Receptor and Potential Drug Target

Olfactory receptor family 11 (OR11) is a subfamily of the T cell receptor (TCR) family that plays a crucial role in the sense of smell. OR11 is composed of two subunits, OR11D and OR11R. OR11D is a 150-kDa alpha chain, while OR11R is a 250-kDa alpha chain.

OR11 is involved in the detection of a wide variety of stimuli, including scents, herbs, and spices. OR11D and OR11R are expressed in the peripheral nervous system (PNS) and central nervous system (CNS), and they are involved in the perception of different types of scents. OR11D is predominantly expressed in the sensory neurons of the vomiting nuclei, while OR11R is predominantly expressed in the taste neurons of the lateral tongue boutique.

OR11D and OR11R differ in their extracellular domain. OR11D has a single extracellular loop at its C-terminus, while OR11R has a double extracellular loop at its C-terminus. OR11D has a single transmembrane region at its D-terminus, while OR11R has a single intracellular loop at its D-terminus.

OR11 is involved in the regulation of various physiological processes, including sensory processing, neurogenesis, and inflammation. OR11D has been shown to play a role in the regulation of neurogenesis, with studies showing that it promotes the proliferation and differentiation of neural stem cells. OR11R has also been shown to be involved in the regulation of inflammation, with studies showing that it enhances the recruitment of immune cells to sites of infection.

Due to its involvement in the sense of smell, OR11 is a potential drug target. Several studies have shown that inhibiting OR11D or OR11R can improve sensory perception, including the perception of scents. For example, one study published in the journal Nature Communications found that inhibiting OR11D reduced the sensitivity to scents in rats, while another study published in the journal Neuroscience found that inhibiting OR11R improved the sensitivity to scents in mice.

In addition to its potential as a drug target, OR11 is also a potential biomarker for various diseases. For example, studies have shown that decreased OR11D expression is associated with an increased risk of developing neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Similarly. , decreased OR11R expression has been shown to be associated with an increased risk of developing various diseases, including cancer and autoimmune diseases.

Overall, OR11H1 (Olfactory receptor family 11 subfamily H member 1) is a protein that is involved in the sense of smell and has been shown to play a role in various physiological processes. Its potential as a drug target and biomarker make it an attractive target for future research. Further studies are needed to fully understand its role in the sense of smell and its potential as a drug and biomarker.

Protein Name: Olfactory Receptor Family 11 Subfamily H Member 1

Functions: Odorant receptor

More Common Targets

OR11H12 | OR11H13P | OR11H2 | OR11H5P | OR11H6 | OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2