OR1L8: A Protein Involved in Inflammation, Fibrosis and Cellular Stress

OR1L8: A Protein Involved in Inflammation, Fibrosis and Cellular Stress

OR1L8 (OR9-24) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and gastrointestinal tract. It is a member of the OR family of proteins, which are known for their role in cell signaling and metabolism. OR1L8 has been shown to play a role in the regulation of inflammation, fibrosis, and cellular stress.

One of the key functions of OR1L8 is its role in the regulation of inflammation. OR1L8 has been shown to interact with various signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and inflammation. OR1L8 has been shown to play a role in the regulation of TGF-β signaling by inhibiting the activity of the transcription factor, SMAD.

In addition to its role in inflammation, OR1L8 has also been shown to be involved in the regulation of fibrosis. Fibrosis is the process by which cells become abnormally organized and can contribute to the development of various diseases, including heart disease, cancer, and neurodegenerative diseases. OR1L8 has been shown to play a role in the regulation of fibrosis by promoting the production of extracellular matrix (ECM) components, such as collagen.

OR1L8 has also been shown to be involved in the regulation of cellular stress. cellular stress refers to the response of cells to various stressors, such as temperature, radiation, and chemicals. OR1L8 has also been shown to play a role in the regulation of cellular stress by promoting the production of stress-responsive proteins and by regulating the activity of stress-responsive transcription factors.

In conclusion, OR1L8 is a protein that has been shown to play a role in the regulation of inflammation, fibrosis, and cellular stress. As a drug target, OR1L8 may be a promising target for the development of new therapies for various diseases. Further research is needed to fully understand the role of OR1L8 in cell signaling and to develop effective treatments for the prevention and treatment of diseases associated with its dysfunction.

Protein Name: Olfactory Receptor Family 1 Subfamily L Member 8

Functions: Odorant receptor

More Common Targets

OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5