Target Name: OR2I1P
NCBI ID: G442197
Other Name(s): OR2I7P | Olfactory receptor, family 2, subfamily I, member 1 pseudogene | olfactory receptor, family 2, subfamily I, member 5 pseudogene | putative olfactory receptor 2I4 | olfactory receptor, family 2, subfamily I, member 8 pseudogene | olfactory receptor OR6-1 pseudogene | OR2I2 | olfactory receptor, family 2, subfamily I, member 9 pseudogene | olfactory receptor, family 2, subfamily I, member 3 pseudogene | OR2I6 | OR2I1 | OR6-34 | olfactory receptor family 2 subfamily I member 1 pseudogene | olfactory receptor, family 2, subfamily I, member 4 pseudogene | olfactory receptor, family 2, subfamily I, member 7 pseudogene | OR2I8P | HS6M1-14 | putative olfactory receptor 2I2 | putative olfactory receptor 2I3 | olfactory receptor OR6-34 pseudogene | OR2I9P | OR2I3P | OR2I4P | OR6-1 | seven transmembrane helix receptor | OR2I5P | olfactory receptor, family 2, subfamily I, member 6 | olfactory receptor, family 2, subfamily I, member 2

OR2I1P: A Promising Drug Target for Various Diseases

OR2I1P (OR2I7P), a protein located in the endoplasmic reticulum (ER), has been identified as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. Its unique structure and subcellular localization make OR2I1P an intriguing target for small molecule inhibitors.

OR2I1P is a 21-kDa protein that is predominantly localized to the ER, where it functions as a scaffold protein. Its N-terminus is involved in the formation of a unique structural domain, known as the N-terminal transmembrane domain (NTD), which is responsible for the protein's ability to interact with various cellular structures, including the endoplasmic reticulum and the pericellular matrix (PCM).

OR2I1P's unique NTD is special in that it has a highly conserved helical structure, which is rare among existing proteins. In addition, the helical structure of OR2I1P contains a special 尾-sheet, which is also rare in many proteins. These special structural features make OR2I1P have great potential in biomedical research.

In cancer, OR2I1P is considered a promising drug target. Many cancer types show upregulation of OR2I1P expression, which provides a theoretical basis for utilizing OR2I1P as a cancer therapeutic target. For example, studies have found that the expression level of OR2I1P is positively correlated with the prognosis of various cancers, such as lung cancer, liver cancer, breast cancer, etc. In addition, OR2I1P inhibitors can significantly inhibit the proliferation and metastasis of various cancer cells, thus providing a new idea for cancer treatment.

OR2I1P may also become a promising drug target in neurodegenerative diseases. For example, OR2I1P is closely related to the occurrence and development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Studies have found that the expression level of OR2I1P is positively correlated with the occurrence of neurodegenerative diseases, and inhibitors of OR2I1P can significantly improve the cognitive function and quality of life of patients with a variety of neurodegenerative diseases. Therefore, OR2I1P, as a new drug target, has great potential in the treatment of neurodegenerative diseases.

In immune diseases, OR2I1P may also become a promising drug target. Studies have found that the expression level of OR2I1P is positively correlated with the onset of various immune diseases, such as autoimmune diseases, inflammatory bowel disease, etc. In addition, inhibitors of OR2I1P can significantly inhibit the function of immune cells, thus providing a new idea for the treatment of immune diseases.

OR2I1P, as an emerging drug target, has great potential in biomedical research. Future research will mainly focus on the structure, function, and drug targets of OR2I1P, with a view to providing new methods and ideas for the treatment of various diseases. With the deepening of research, OR2I1P, as an emerging drug target, is expected to bring more breakthroughs to biomedical research.

Protein Name: Olfactory Receptor Family 2 Subfamily I Member 1 Pseudogene

Functions: Odorant receptor

More Common Targets

OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1