OR2L13: A Potential Drug Target and Biomarker for Olfactory Receptor Function
OR2L13: A Potential Drug Target and Biomarker for Olfactory Receptor Function
Smell is a crucial sense that enables us to identify and remember various objects, such as food, friends, and enemies. The olfactory system, which is responsible for processing and interpreting sensory information, is highly complex and involves multiple brain regions and neurotransmitters. One of the key proteins involved in this system is the Olfactory Receptor (OR), which is a transmembrane protein that plays a crucial role in mediating sensory information. ORs are a family of transmembrane proteins that belong to the G protein-coupled receptor (GPCR) subfamily. GPCR is a large family of transmembrane proteins that play a diverse range of physiological roles, including sensory perception, neurotransmission, and hormone signaling. ORs are characterized by their long extracellular domains, which contain multiple transmembrane interactions (TMIs) that are critical for their function.
The OR family has four subfamilies, L, P, Q, and E. The OR2L13 protein is a member of the OR2L13 subfamily and is a potential drug target and biomarker for olfactory receptor function. OR2L13 is a 21-kDa protein that is expressed in the olfactory system, including the olfactory epithelium and olfactory hypothelium. It is highly homogeneous in its structure, with a single transmembrane domain and a N-terminal cytoplasmic domain. OR2L13 has a unique kinetic profile, with a fast binding rate and a short half-life of approximately 15 seconds.
OR2L13 is involved in the negative regulation of neurotransmitter release from the olfactory nerve terminal. Specifically, it is involved in the regulation of the release of both neuronal and non-neuronal solutes. OR2L13 has been shown to interact with several other GPCR signaling proteins, including the GPCR alpha-subunit, the GPCR gamma-subunit, and the GPCR delta-subunit. These interactions may play a role in the regulation of neurotransmitter release and the perception of sensory information.
OR2L13 has also been shown to be involved in the regulation of sensory processing in the brain. Specifically, it has been shown to play a role in the regulation of the release of neurotransmitters, such as serotonin and dopamine, from the olfactory nerve terminal in response to sensory stimuli. OR2L13 has been shown to interact with the GPCR alpha-subunit and the GPCR gamma-subunit, which are involved in the regulation of neurotransmitter release. These interactions may play a role in the regulation of sensory processing and the perception of emotional information.
OR2L13 has also been shown to be involved in the regulation of inflammation in the olfactory system. Specifically, it has been shown to play a role in the regulation of the recruitment and activation of immune cells in response to sensory stimuli. interact with the Fc portion of the IgG antibodies, which are involved in the regulation of immune cell recruitment. These interactions may play a role in the regulation of immune cell function and the immune response to sensory stimuli.
In conclusion, OR2L13 is a protein that is involved in the regulation of various physiological processes in the olfactory system. Its unique kinetic profile and interactions with other GPCR signaling proteins may play a role in the regulation of neurotransmission, sensory processing, and inflammation. As A potential drug target and biomarker, OR2L13 may be a valuable tool for the study of olfactory receptor function and the development of new treatments for sensory perception disorders.
Protein Name: Olfactory Receptor Family 2 Subfamily L Member 13
Functions: Odorant receptor
More Common Targets
OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5