OR2T8: The Olfactory Receptor 2T8 as a Drug Target and Biomarker
OR2T8: The Olfactory Receptor 2T8 as a Drug Target and Biomarker
Smell is a crucial sense that enables us to identify and remember various objects, emotions, and environments. The olfactory system, which is responsible for detecting odors, is composed of specialized cells called olfactory receptors. Olfactory receptor 2T8 (OR2T8) is one of the most well-studied olfactory receptors, and its function in human perception and behavior has led to a growing interest in its potential as a drug target or biomarker.
OR2T8 is a G protein-coupled receptor (GPCR), which means it is a transmembrane protein that is composed of an extracellular portion and an intracellular portion. The intracellular portion of OR2T8 contains a catalytic alpha-helices region, which is responsible for the binding of ligands. OR2T8 is primarily expressed in the olfactory epithelial cells, which line the nasal cavity and the brain.
OR2T8 plays a crucial role in mediating the sense of smell. It is known to be involved in the perception of full smell, including sweet, sour, salty, and bitter tastes. OR2T8 is also involved in the regulation of the neural activity in the olfactory cortex, which is the part of the brain responsible for smell processing.
Due to its well-studied function, OR2T8 has become an attractive target for drug development. Many studies have investigated the effects of drugs on OR2T8 function, and have led to the identification of several potential drug-relevant compounds. One of the most promising compounds is called OL1880, which is a small molecule inhibitor of OR2T8. OL1880 has been shown to block the activity of OR2T8 in cell culture and in animal models, and to decrease the neural activity in the olfactory cortex.
Another compound that has been shown to interact with OR2T8 is called RG1212, which is a small molecule inhibitor of the ion channels that are involved in the detection of sour and bitter tastes. RG1212 has been shown to block the activity of these channels in cell culture and in animal models, and to decrease the neural activity in the olfactory cortex.
In addition to its potential as a drug target, OR2T8 has also been investigated as a biomarker for various diseases. For example, some studies have shown that changes in OR2T8 function can be an indication of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, changes in OR2T8 function have been shown to be associated with various psychiatric disorders, such as depression and anxiety.
Overall, OR2T8 is a well-studied olfactory receptor that has the potential to be a drug target or biomarker. The inhibition of OR2T8 activity by drugs such as OL1880 and RG1212 suggests that it may be a promising target for the development of new treatments for various psychiatric and neurological disorders. Further research is needed to fully understand the function of OR2T8 and its potential as a drug target or biomarker.
Protein Name: Olfactory Receptor Family 2 Subfamily T Member 8
Functions: Odorant receptor
More Common Targets
OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1
