Target Name: OR2B3
NCBI ID: G442184
Other Name(s): OR2B3P | hs6M1-1 | olfactory receptor OR6-14 | Olfactory receptor OR6-14 | olfactory receptor 6-4 | OR2B3_HUMAN | OR6-14 | OR6-4 | Olfactory receptor 6-4 | Putative olfactory receptor 2B3 | 6M1-1 | Olfactory receptor, family 2, subfamily B, member 3 | olfactory receptor family 2 subfamily B member 3 | Olfactory receptor family 2 subfamily B member 3 | Olfactory receptor 2A3 | Hs6M1-1

OR2B3P: A GPCR Targeted for Neurological Disorders

OR2B3 (OR2B3P), a protein that is expressed in the brain, has been identified as a potential drug target (OR2B3P) and a biomarker for various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. OR2B3P is a transmembrane protein that is involved in the regulation of pain perception, anxiety, and depression. It is a G protein-coupled receptor (GPCR), which means that it interacts with intracellular signaling pathways that regulate the function of neurons and other cells in the brain.

Studies have shown that OR2B3P is involved in the development and progression of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. It is thought to play a role in the development of these disorders by contributing to the dysfunction of the endocannabinoid system ( ES), which is the system that regulates the availability of endocannabinoids in the brain.

In addition to its involvement in the development of neurological disorders, OR2B3P has also been shown to be a potential drug target. Studies have shown that inhibiting OR2B3P can lead to the reversal of several neurological symptoms, including the improvement of memory, learning, and motor function in animal models of Alzheimer's disease. OR2B3P has also been shown to be a potential biomarker for Alzheimer's disease, with studies showing that its levels are significantly increased in the brains of individuals with Alzheimer's disease compared to those without the disease.

OR2B3P is a GPCR, which means that it consists of a transmembrane domain and an intracellular loop. The transmembrane domain is involved in the regulation of the activity of the protein, while the intracellular loop is involved in the regulation of its stability and interactions with other proteins.

The function of OR2B3P is thought to be related to the regulation of the endocannabinoid system. Endocannabinoids are naturally occurring compounds that are derived from the cannabis plant. They are involved in the regulation of various physiological processes in the brain, including pain perception, anxiety, and mood regulation. The endocannabinoid system is a complex system that is responsible for the regulation of the availability and activity of endocannabinoids in the brain.

Inhibition of OR2B3P has been shown to increase the activity of several endocannabinoids, including 2-arachidonoylglycerol (2-AG) and 2-arachidonoylglycerol receptor (2-ARGPR). These endocannabinoids are involved in the regulation of pain perception, anxiety, and mood regulation . The increased activity of these endocannabinoids may contribute to the improvement of these symptoms in animal models of Alzheimer's disease.

In addition to its involvement in the regulation of the endocannabinoid system, OR2B3P is also thought to be involved in the regulation of other signaling pathways in the brain. For example, it has been shown to be involved in the regulation of the activity of dopamine, a neurotransmitter that is involved in the regulation of mood, emotion, and motivation.

The potential drug targeting of OR2B3P is an exciting area of 鈥嬧?媟esearch, as it has the potential to contribute to the treatment of several neurological disorders. Studies have shown that inhibiting OR2B3P can lead to the reversal of several neurological symptoms, including the improvement of memory, learning, and motor function in animal models of Alzheimer's disease. Further studies are needed to determine the effectiveness of OR2B3P as a drug target

Protein Name: Olfactory Receptor Family 2 Subfamily B Member 3

Functions: Odorant receptor

More Common Targets

OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5