Target Name: OR2F1
NCBI ID: G26211
Other Name(s): Olfactory receptor, family 2, subfamily F, member 4 | OR7-140 | OR2F5 | OR2F3P | OR14-60 | OR7-139 | Olfactory receptor OR7-7 | Olfactory receptor, family 2, subfamily F, member 5 | olfactory receptor family 2 subfamily F member 1 | olfactory receptor OR7-7 | 7M1-2 | OR2F3 | Olfactory receptor 2F5 | olfactory receptor 2F5 | Olfactory receptor 2F3 | Olfactory receptor 2F1 | Olfactory receptor-like protein OLF3 | OLF3 | OR2F4 | olfactory receptor 2F3 | Olfactory receptor 2F4 | olfactory receptor 2F4 | Olfactory receptor, family 2, subfamily F, member 3 | olfactory receptor, family 2, subfamily F, member 3 | olfactory receptor, family 2, subfamily F, member 4 | olfactory receptor, family 2, subfamily F, member 5 | OR2F1_HUMAN | Olfactory receptor, family 2, subfamily F, member 1 | Olfactory receptor family 2 subfamily F member 1 | olfactory receptor-like protein OLF3

OR2F1: A Potential Drug Target and Biomarker for Olfactory Receptor Function

Smell is a crucial sense that enables us to identify and remember various objects, emotions, and environments. The olfactory system, which is responsible for processing and interpreting smells, is composed of specialized cells called olfactory receptors. Olfactory receptor, family 2 (OR2F1) is one of the most well-known olfactory receptor family members, located in the gene OR2F1. OR2F1 plays a crucial role in human olfactory function, and its dysfunction has been linked to various neurological and psychiatric disorders. As a result, targeting OR2F1 has emerged as a promising strategy for the development of new treatments for disorders with altered sensory perception. In this article, we will discuss OR2F1 as a drug target and biomarker, highlighting its current status in research and its potential as a therapeutic approach.

OR2F1 Structure and Function

OR2F1 is a transmembrane protein that belongs to the olfactory receptor family 2. This family is composed of three subfamilies, including OR2F1, OR2F2, and OR2F3. OR2F1 is a 191-amino acid protein that contains a N-terminus, a single transmembrane region, and a C-terminus. The N-terminus of OR2F1 is involved in the formation of a complex with a specific protein called G protein-coupled receptor (GPCR) ligand, which is responsible for transmitting olfactory signals to the central nervous system (CNS ).

OR2F1 is a key member of the Olfactory Receptor family, which is involved in the perception of various odors, including scents, herbs, and environmental stimuli. OR2F1 is expressed in various tissues of the body, including the brain, sensory neurons, and the vomiting humor. It is well established that OR2F1 plays a crucial role in the processing and interpretation of smells, which are critical for our survival and quality of life.

OR2F1 dysfunction in neurological and psychiatric disorders

Disruptions in OR2F1 function have been implicated in the development and progression of various neurological and psychiatric disorders. OR2F1 dysfunction has been associated with several disorders, including:

1. Alzheimer's disease: Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. Several studies have suggested that OR2F1 dysfunction may be involved in the development and progression of this disease.
2. Parkinson's disease: Parkinson's disease is a neurodegenerative disorder that is characterized by the loss of dopamine-producing neurons in the brain. Similarly, OR2F1 dysfunction has been implicated in the development and progression of Parkinson's disease.
3. Smell disorders: Smell disorders, such as olfactory agnosia (olfactory agnosia), are characterized by a loss of normal olfactory function. Several studies have suggested that OR2F1 dysfunction may be involved in the development and progression of these disorders.
4. Psychiatric disorders: OR2F1 dysfunction has also been implicated in the development and progression of various psychiatric disorders, including depression, anxiety, and schizophrenia.

OR2F1 as a drug target and biomarker

Targeting OR2F1 has emerged as a promising strategy for the development of new treatments for disorders with altered sensory perception. Several studies have shown that blocking OR2F1 function can improve sensory function in various models of disease.

1. olfactory receptor function: Several studies have demonstrated that inhibiting OR2F1 function can improve sensory function, including the ability to detect and identify odors, in both healthy and disease states.
2. efficacy of OR2F1 antagonists: Several studies have shown that OR2F1 antagonists can improve sensory function in various models of disease, including

Protein Name: Olfactory Receptor Family 2 Subfamily F Member 1

Functions: Odorant receptor

More Common Targets

OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15