Olfactory Receptor OR2AT4 as A Drug Target and Biomarker (G341152)

Olfactory Receptor OR2AT4 as A Drug Target and Biomarker

Olfactory receptor OR11-265 (OR2AT4) is a protein that is expressed in the olfactory system, which is responsible for the sense of smell. OR2AT4 is a G protein-coupled receptor (GPCR), which is a family of transmembrane proteins that play an important role in sensory perception.

The olfactory system is one of the five senses that the human body uses to perceive the world around us. The sense of smell is responsible for detecting and identifying the chemical compounds in the air that are responsible for our sense of smell. The olfactory system is made up of a complex array of neurons and neurotransmitters that work together to allow us to perceive the world around us.

OR2AT4 is one of the proteins that is involved in this process. It is a GPCR that is expressed in the olfactory system and is involved in the sense of smell. OR2AT4 is a key mediator of the olfactory response, as it is responsible for the detection and perception of scents.

One of the interesting things about OR2AT4 is its potential as a drug target. Due to its involvement in the olfactory system, researchers and pharmaceutical companies are interested in using OR2AT4 as a potential drug target for a variety of neurological and psychiatric disorders.

One of the reasons for OR2AT4's potential as a drug target is its location in the brain. The olfactory system is located in the midbrain, which is a part of the brain that is responsible for the sense of smell. This location makes OR2AT4 an attractive target for drugs that are designed to modulate the activity of neurons in the olfactory system.

Another reason for OR2AT4's potential as a drug target is its role in the development of certain neurological disorders. For example, research has suggested that OR2AT4 may be involved in the development of Alzheimer's disease, a progressive neurodegenerative disorder that is characterized by the accumulation of beta-amyloid plaques in the brain.

Additionally, OR2AT4 has also been shown to be involved in the development of other neurological disorders, such as Parkinson's disease and schizophrenia. These disorders are characterized by the disruption of normal brain function, and they can be treated with drugs that target OR2AT4.

OR2AT4 is also of interest as a potential biomarker for certain neurological disorders. The olfactory system is involved in the production of proteins that are involved in the development and progression of many neurological disorders. OR2AT4 is one of these proteins, and its levels have been shown to be altered in the brains of individuals with certain neurological disorders.

Research has also suggested that changes in the levels of OR2AT4 may be an indication of certain neurological disorders. For example, individuals with Alzheimer's disease have been shown to have lower levels of OR2AT4 compared to healthy individuals. Similarly, individuals with Parkinson's disease have been shown to have higher levels of OR2AT4 compared to healthy individuals.

Despite the potential benefits of OR2AT4 as a drug target and biomarker, there are also concerns about its use in certain contexts. For example, some have raised concerns about the potential side effects of drugs that target OR2AT4, such as increased thirst or the urge to urinate.

Additionally, there are also concerns about the ethical implications of using OR2AT4 as a drug target or biomarker. For example, there are concerns about the potential for these drugs to be used to treat individuals who are not suffering from neurological disorders, or about the potential for these drugs to be used to diagnose individuals who do not have a neurological disorder.

In conclusion, OR2AT4 is a protein that is expressed in the olfactory system and is involved in the sense of smell. Its potential as a drug target and biomarker has

Protein Name: Olfactory Receptor Family 2 Subfamily AT Member 4

Functions: Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264)

More Common Targets

OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29