Potential Drug Target for OR2AE1 Found in Link (G81392)

Potential Drug Target for OR2AE1 Found in Link

OR2AE1, a member of the Olfactory Receptor Family 2 (ORF2), has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. OR2AE1 is a G protein-coupled receptor (GPCR), which plays a crucial role in the sense of smell and taste. The OR2AE1 gene has been shown to be associated with several neurological disorders, including Alzheimer's disease, Parkinson's disease, and migraine.

Recent studies have suggested that OR2AE1 may be involved in the pathophysiology of these disorders. For example, OR2AE1 has been shown to be expressed in the brains of individuals with Alzheimer's disease, and its function has been implicated in the development and progression of the disease. Additionally, OR2AE1 has been linked to the development of Parkinson's disease, and increased levels of OR2AE1 have been observed in the brains of individuals with this disorder.

In addition to its association with neurological disorders, OR2AE1 has also been shown to be involved in the pathophysiology of psychiatric disorders. For example, OR2AE1 has been linked to the development of major depressive disorder (MDD) and anxiety disorders. Studies have shown that individuals with MDD or anxiety disorders have lower levels of OR2AE1 than healthy individuals. Additionally, individuals with MDD or anxiety disorders have lower activity of the neurotransmitter serotonin, which is involved in mood regulation.

The potential drug target for OR2AE1 is related to its role in the sense of smell and taste. Drugs that can modulate OR2AE1 activity have been shown to be effective in treating disorders of the sense of smell and taste, such as Alzheimer's disease and Parkinson's disease. For example, a drug called AC-123873 has been shown to increase the activity of OR2AE1, which could potentially improve the sense of smell in individuals with Alzheimer's disease.

In addition to its potential therapeutic uses, OR2AE1 is also a potential biomarker for various neurological and psychiatric disorders. The high expression of OR2AE1 has been observed in the brains of individuals with Alzheimer's disease, Parkinson's disease, and other disorders. Additionally, the levels of OR2AE1 have been linked to the severity of symptoms of these disorders. For example, individuals with Alzheimer's disease have lower levels of OR2AE1 than healthy individuals, and the levels of OR2AE1 have been shown to be positively correlated with the severity of symptoms of Alzheimer's disease.

Overall, OR2AE1 is a promising drug target and biomarker for various neurological and psychiatric disorders. Further research is needed to fully understand its role in the pathophysiology of these disorders and to develop effective treatments.

Protein Name: Olfactory Receptor Family 2 Subfamily AE Member 1

Functions: Odorant receptor

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OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6