OR1J4: A GPCR Molecule Exploring Smell and Saliva Production (G26219)

OR1J4: A GPCR Molecule Exploring Smell and Saliva Production

Olfactory receptor OR9-21 is a G protein-coupled receptor (GPCR) that is expressed in the human nose and is responsible for mediating the sense of smell. OR1J4 is a specific subunit of OR9-21 that is expressed in the vomiting pharyngeal area (VPA) of the nose. The VPA is the area of the nose that is responsible for producing saliva and is home to a diverse array of sensory neurons that are responsible for transmitting information about the taste and texture of food to the brain.

OR1J4 is a key mediator of the sense of smell in the VPA. It is involved in the perception of a wide range of sensory stimuli, including scents, such as those associated with food, drugs, and environmental chemicals. OR1J4 is also involved in the regulation of the production of saliva, which is critical for maintaining the proper environment for the taste and texture of food to be perceived.

OR1J4 is a potential drug target for a variety of therapeutic applications. One of the main reasons for its potential as a drug target is its involvement in the sense of smell. The loss of sense of smell can be a common side effect of many medications, including those used to treat chronic pain, cancer, and other conditions. Therefore, targeting OR1J4 with drugs that can restore or enhance sense of smell could be a promising approach to treating these conditions.

In addition to its role in the sense of smell, OR1J4 is also a potential biomarker for a variety of diseases. The production of saliva is a critical function for the immune system, and the failure of the salivary glands to function properly can be a sign of underlying immune system disorders. Therefore, studying the role of OR1J4 in the regulation of saliva production could provide valuable insights into the underlying mechanisms of immune system disorders.

OR1J4 is also a potential target for studying the effects of drugs on the development and progression of various diseases. For example, the production of saliva is a critical factor in the development and progression of cancer, and drugs that can modulate OR1J4 activity could be useful in the treatment of this disease. Additionally, the regulation of saliva production is also involved in the pathogenesis of a variety of other diseases, including neurodegenerative disorders, allergies, and autoimmune diseases. Therefore, targeting OR1J4 with drugs that can modulate its activity could be a promising approach to treating a wide range of diseases.

In conclusion, OR1J4 is a GPCR that is involved in the sense of smell and the regulation of saliva production. Its potential as a drug target and biomarker make it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of OR1J4 in the regulation of saliva production and its potential as a drug and biomarker.

Protein Name: Olfactory Receptor Family 1 Subfamily J Member 4

Functions: Odorant receptor

More Common Targets

OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29 | OR2T3 | OR2T33 | OR2T34 | OR2T35 | OR2T4 | OR2T5 | OR2T6 | OR2T7 | OR2T8 | OR2U1P | OR2V1 | OR2V2 | OR2W1 | OR2W1-AS1 | OR2W3 | OR2W5P | OR2W6P | OR2Y1 | OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P