OR12D2: A G-Coupled Receptor Involved in Pain and Cardiovascular Signaling

OR12D2: A G-Coupled Receptor Involved in Pain and Cardiovascular Signaling

OR12D2 (Hs6M1-20), a protein encoded by the human gene OR12D2, is a member of the superfamily of proteins known as G-coupled receptors (GCRs). GCRs are a family of transmembrane proteins that play a central role in cellular signaling, specifically in the regulation of gene expression and cell signaling pathways. OR12D2 is a GCR that is expressed in various tissues and organs, including the brain, heart, and peripheral tissues.

The OR12D2 gene was first identified in 2003 using DNA-based techniques, and its function and structure have been extensively studied since then. OR12D2 is a 21-kDa protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is responsible for the protein's stability and function, as well as its ability to interact with other proteins. The transmembrane region is responsible for the protein's unique structure and its ability to interact with ligands, while the intracellular domain is responsible for the protein's ability to interact with intracellular signaling pathways.

OR12D2 is a GCR that is involved in a wide range of physiological processes, including cardiovascular, neurodegenerative, and pain signaling pathways. One of the most well-studied functions of OR12D2 is its role in pain signaling. OR12D2 is known to be involved in the regulation of pain perception and tolerance, and is thought to play a key role in the development of chronic pain conditions.

In addition to its role in pain signaling, OR12D2 is also involved in a number of other physiological processes, including cardiovascular function, neurotransmission, and cell signaling. For example, OR12D2 is known to be involved in the regulation of neurotransmitter release from neurons, and is thought to play a key role in the development of neurodegenerative diseases such as Alzheimer's disease. OR12D2 is also involved in the regulation of cell signaling pathways, including the regulation of cell growth, differentiation, and survival.

Due to its involvement in a wide range of physiological processes, OR12D2 is a promising drug target for a variety of diseases. For example, OR12D2 has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease, and is thought to play a key role in the regulation of pain perception and tolerance. Additionally, OR12D2 has also been shown to be involved in the regulation of cardiovascular function, and is thought to play a key role in the development of cardiovascular disease.

In conclusion, OR12D2 is a GCR that is involved in a wide range of physiological processes, including pain signaling, neurotransmission, and cell signaling pathways. Its function and structure have been extensively studied, and it is a promising drug target for a variety of diseases. Further research is needed to fully understand the role of OR12D2 in these processes, and to develop effective therapies for the treatment of diseases associated with its dysfunction.

Protein Name: Olfactory Receptor Family 12 Subfamily D Member 2

Functions: Odorant receptor

More Common Targets

OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2