Target Name: OR10AA1P
NCBI ID: G81487
Other Name(s): Olfactory receptor family 10 subfamily AA member 1 pseudogene | olfactory receptor family 10 subfamily AA member 1 pseudogene

OR10AA1P: A Potential Drug Target and Biomarker

Introduction

The olfactory system is a crucial aspect of human sensory function, responsible for mediating the sense of smell. OR10AA1P, a member of the Olfactory Receptor Family 10 (ORF10), has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders . In this article, we will provide an overview of OR10AA1P, its functions, potential drug targets, and its potential as a biomarker.

OR10AA1P: Structure and Function

OR10AA1P is a 194 amino acid protein that belongs to the Olfactory Receptor Family 10 (ORF10). It is characterized by the presence of a long N-terminus, a single transmembrane segment, and a C-terminus that contains a Gly-rich region and a putative G protein-coupled receptor (GPCR) domain.

OR10AA1P is expressed in various tissues and cell types, including the brain, pancreatic islet, and peripheral tissues. It is known to play a role in the sense of smell, specifically in the detection of sweet and sour odors. OR10AA1P has been shown to interact with several other proteins, including the GPCR domain of the olfactory receptor, the neurotransmitter receptor NAD+, and the transcription factor miR-202.

OR10AA1P as a Drug Target

OR10AA1P has been identified as a potential drug target due to its involvement in several neurological and psychiatric disorders. Several studies have shown that alterations in OR10AA1P levels or its function have been implicated in the development and progression of various psychiatric and neurological disorders, including Alzheimer's disease , Parkinson's disease, and depression.

One of the potential drug targets for OR10AA1P is the neurotransmitter serotonin, which is involved in mood regulation and other cognitive processes. Studies have shown that increased levels of OR10AA1P have been associated with increased levels of serotonin in the brain, and that inhibition of OR10AA1P has has been shown to improve mood in animal models of depression.

Another potential drug target for OR10AA1P is the GPCR domain, which has been shown to interact with several neurotransmitters and ion channels involved in neurotransmission. Therefore, compounds that can interact with the GPCR domain of OR10AA1P may be expected to have anxiolytic or antidepressant effects.

OR10AA1P as a Biomarker

OR10AA1P has also been identified as a potential biomarker for various neurological and psychiatric disorders. The reliable and Validated Research (RViR) system is a scoring system that can be used to evaluate the quality of brain imaging studies, and has been used to evaluate the relationship between OR10AA1P and brain activity in individuals with depression.

In addition, OR10AA1P has been shown to be expressed in the brains of individuals with Alzheimer's disease, and levels of OR10AA1P have been shown to be decreased in individuals with Alzheimer's disease compared to age-matched controls. Therefore, OR10AA1P may be a potential biomarker for Alzheimer's disease and could be used as a diagnostic tool in combination with other diagnostic tests.

Conclusion

OR10AA1P is a protein that has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its functions include the detection of sweet and sour odors and its interaction with the GPCR domain of the olfactory receptor, as well as its potential role in the neurotransmitter serotonin and the GPCR domain. Further research is needed to fully understand the role of OR10AA1P in

Protein Name: Olfactory Receptor Family 10 Subfamily AA Member 1 Pseudogene

More Common Targets

OR10AB1P | OR10AC1 | OR10AD1 | OR10AF1P | OR10AG1 | OR10AK1P | OR10C1 | OR10D1P | OR10D3 | OR10D4P | OR10G2 | OR10G3 | OR10G4 | OR10G7 | OR10G8 | OR10G9 | OR10H1 | OR10H2 | OR10H3 | OR10H4 | OR10H5 | OR10J1 | OR10J2P | OR10J3 | OR10J5 | OR10K1 | OR10K2 | OR10P1 | OR10Q1 | OR10R2 | OR10S1 | OR10T2 | OR10V1 | OR10W1 | OR10X1 | OR10Z1 | OR11A1 | OR11G2 | OR11H1 | OR11H12 | OR11H13P | OR11H2 | OR11H5P | OR11H6 | OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1