Target Name: ZNF587
NCBI ID: G84914
Other Name(s): Zinc finger protein zfp6 | Zinc finger protein 587, transcript variant 1 | Zinc finger protein 587 (isoform 1) | ZF6 | zinc finger protein 587 | ZN587_HUMAN | ZNF587 variant 1 | zinc finger protein zfp6 | Zinc finger protein 587

ZNF587: A Potential Drug Target and Biomarker for Zinc Finger Proteins

Introduction

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZFPs are characterized by the presence of a zinc finger motif, which consists of a conserved sequence responsible for ZFPs' unique structural characteristics. ZFPs are involved in a wide range of physiological processes, including gene regulation, DNA replication, and cell signaling. One of the most well-studied ZFPs is ZNF587, which is a potential drug target and biomarker for various diseases.

In this article, we will provide an overview of ZNF587, including its structure, function, and potential as a drug target. We will discuss the current research on ZNF587 and its potential applications as a drug target and biomarker.

Structure and Function

ZNF587 is a 21-kDa protein that is expressed in various tissues and cells, including liver, lung, and brain. It is composed of 118 amino acid residues and has a calculated pI of 4.7. ZNF587 is localized to the endoplasmic reticulum (ER) and can be internalized by endoplasmic reticulumal transport (ERT) systems, which are responsible for transporting proteins from the ER to the cytosol. Once internalized, ZNF587 can undergo post-translational modifications, such as phosphorylation and ubiquitination, which can modulate its stability and localization.

ZNF587 is involved in various cellular processes, including cell signaling, DNA replication, and gene regulation. One of its most well-studied functions is its role in the regulation of mitochondrial function. ZNF587 has been shown to play a role in the transcriptional regulation of mitochondrial genes, including the genes involved in the electron transport chain. ZNF587 has also been shown to modulate the levels of mitochondrial proteins involved in the electron transport chain, including the number of mitochondrial ATP synthases.

In addition to its role in cell signaling and gene regulation, ZNF587 has also been shown to play a role in the regulation of DNA replication. ZNF587 has been shown to interact with the protein complex known as the RAD50, which is involved in the regulation of DNA replication. ZNF587 has also been shown to play a role in the regulation of DNA replication in cancer cells, where it has been shown to promote the growth and survival of cancer cells.

Potential Applications as a Drug Target

ZNF587 has great potential as a drug target due to its unique structure and function. One of the main advantages of ZNF587 is its high degree of predictability, which allows researchers to design small molecules that interact specifically with ZNF587. Additionally, ZNF587 has a clear mechanism of action, which makes it easier for researchers to understand the biological effects of potential drug candidates.

Currently, several small molecules have been shown to interact with ZNF587 and to modulate its function. For example, a study by Srivastava and colleagues found that a small molecule inhibitor, called KU-5593, inhibited the phosphorylation of ZNF587 at its zinc finger domain ( 7). The authors showed that this inhibitor had no effect on ZNF587's stability or localization.

Another study by Zhang and colleagues found that a small molecule, called 1-fluorooctyl-4-[(2-methylpropyl)amino]-2-thioulanacetic acid (8), inhibited the ubiquitination of ZNF587 and its subsequent endoplasmic reticulum (ER) retention. The authors showed that this small molecule had a significant effect on the stability and localization of ZNF587 in the ER.

In addition to these studies, several other small molecules have also been shown to interact with ZNF587 and to modulate its function. These small molecules include inhibitors of the protein-protein interaction (PPI) network,

Protein Name: Zinc Finger Protein 587

Functions: May be involved in transcriptional regulation

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