Target Name: LMO4
NCBI ID: G8543
Other Name(s): LMO4 variant 1 | Breast tumor autoantigen | LIM domain only protein 4 | LIM-only protein 4 | LIM domain only 4 | LMO-4 | LIM domain transcription factor LMO4 | breast tumor autoantigen | LMO4_HUMAN | LIM domain only 4, transcript variant 1 | LIM-only 4 protein

Implications of LMO4 as A Potential Drug Target and Biomarker

LMO4 (LMO4 variant 1) is a protein that is expressed in various tissues of the human body, including the liver, pancreas, and muscle. It is a member of the leucine-rich repeat (LRR) family of proteins, which are known for their role in various cellular processes, including inflammation, metabolism, and signaling.

Recent studies have identified LMO4 as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is due to LMO4's unique structure and its ability to interact with a variety of molecules, including drugs and diseases.

One of the key features of LMO4 is its ability to form inclusion bodies, which are clusters of the protein within cells. These inclusion bodies can interact with a variety of intracellular molecules, including proteins that are involved in signaling pathways and metabolism. This interaction between LMO4 and these molecules has important implications for the regulation of cellular processes and the development of diseases.

In addition to its role in cellular signaling, LMO4 has also been shown to play a key role in the development and progression of certain diseases. For example, LMO4 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. This is due to LMO4's ability to interact with the protein tau, which is involved in the formation of neurofibrillary tangles and the destruction of nerve cells in these diseases.

Another potential mechanism by which LMO4 may contribute to the development of certain diseases is its role in inflammation. LMO4 has been shown to play a key role in the production and regulation of pro-inflammatory cytokines, which are involved in the inflammatory response. This interaction between LMO4 and inflammation may contribute to the development of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis.

The potential drug targeting of LMO4 also comes from its potential ability to interact with drugs that are currently used to treat various diseases. For example, LMO4 has been shown to interact with drugs that are used to treat cancer, including taxanes and vinca alkaloids. This may suggest that LMO4 could be a useful target for cancer treatment, particularly in cases where traditional chemotherapy may be effective in targeting this protein.

In conclusion, LMO4 is a protein that has important roles in various cellular processes and has been implicated in the development and progression of a variety of diseases. Its unique structure and ability to interact with a variety of molecules make it a promising target for drug development and research into the underlying mechanisms of these diseases. Further studies are needed to fully understand the role of LMO4 in disease and to develop effective treatments.

Protein Name: LIM Domain Only 4

Functions: Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons

More Common Targets

LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987 | LOC100130992 | LOC100131096 | LOC100131107 | LOC100131257 | LOC100131289 | LOC100131372 | LOC100131496 | LOC100131532 | LOC100131626 | LOC100131635 | LOC100131859 | LOC100131877 | LOC100131943 | LOC100132004 | LOC100132062 | LOC100132077 | LOC100132078 | LOC100132249 | LOC100132287 | LOC100132356 | LOC100132609 | LOC100132626