TMEM263: A Transmembrane Protein in the Fray for Drug Targets and Biomarkers

Target Name: TMEM263

NCBI ID: G90488

TMEM263: A Transmembrane Protein in the Fray for Drug Targets and Biomarkers

Introduction

TMEM263, also known as Transmembrane protein 263 (ISOform A), is a protein that plays a crucial role in various cellular processes. It is a member of the TMEM family, which is known for its transmembrane characteristics and diverse functions in various organisms. TMEM263 is widely expressed in various tissues and cells, including the brain, heart, liver, and kidney, making it an attractive candidate for potential drug targets or biomarkers.

Drug Targets

TMEM263 has been identified as a potential drug target due to its unique structure and various functions. One of its defining features is its transmembrane character, which allows it to interact with both intrinsic and extrinsic ligands. Intrinsic ligands include ligands in protein interaction networks, while extrinsic ligands include lipids, sugars, and other molecules. This property of TMEM263 enables it to interact with a variety of molecules, thus providing more possibilities for drug development and design.

In addition, TMEM263 also plays an important role in cell signaling. In neurons, TMEM263 regulates calcium ion influx and neuronal excitability by interacting with voltage-dependent calcium channels (Ca2+ channels). This interaction is not only critical for the normal function of neurons, but also has great potential for the treatment of neuronal diseases.

TMEM263 also shows promise in tumor cells. Studies have shown that TMEM263 is up-regulated in a variety of tumor cells and is closely related to the growth and invasion of tumor cells. Therefore, TMEM263 is considered a potential tumor target.

Biomarkers

In addition to being a drug target, TMEM263 also has potential as a biomarker. Because TMEM263 is highly expressed in a variety of tissues and organs, it can be used to detect early stages of disease and monitor the effectiveness of treatments. For example, TMEM263 can be used for the diagnosis of liver cirrhosis because the liver is one of the tissues with the highest expression of TMEM263.

TMEM263 can also be used to detect kidney disease, as the kidney is one of the organs with high TMEM263 expression. Research shows that TMEM263 can be used to detect and evaluate glomerular filtration rate (GFR), thereby helping doctors evaluate the severity and prognosis of kidney disease.

TMEM263 can also be used to detect other diseases, such as diabetes, obesity, atherosclerosis and inflammation. For example, studies have shown that TMEM263 can be used to detect blood sugar levels in diabetic patients, thereby helping doctors evaluate the effectiveness of patient treatment.

Conclusion

TMEM263 is a protein with great promise as a drug target or biomarker. Because it is highly expressed in a variety of tissues and organs, TMEM263 can be used to detect a variety of diseases, including tumors, cirrhosis, diabetes, obesity, atherosclerosis, and inflammation. In the future, TMEM263 will play a more important role in drug research and biomedical research.

Protein Name: Transmembrane Protein 263

Functions: May play a role in bone development

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