Target Name: TENM3-AS1
NCBI ID: G90768
Other Name(s): TENM3 antisense RNA 1, transcript variant 1 | TENM3 antisense RNA 1

TENM3-AS1: A Potential Drug Target and Biomarker for neurodegenerative Disorders

Abstract:

TENM3-AS1, an RNA chaperone, has been found to be associated with multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Alzheimer's disease-related cerebellar ataxia. Overexpression and deletion of TENM3-AS1 leads to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases. In addition, the association of TENM3-AS1 with neurodegenerative diseases also suggests that it may be a potential drug target or biomarker. This article will elaborate on the mechanism of action, pathological mechanism and potential of TENM3-AS1 as a drug target or biomarker.

1 Introduction

TENM3 (Ten-Translated Neurotrophic M molecule 3) is a genetically encoded RNA chaperone that plays a key role in maintaining neuronal survival and synaptic variability. The RNA molecule encoded by the TENM3 gene interacts with neuron-specific proteins and affects the repair and regeneration of neurons after injury. TENM3-AS1 is an intron of the TENM3 gene, and its encoded RNA functions in neurons. Overexpression and deletion of TENM3-AS1 leads to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases.

2. Mechanism of action of TENM3-AS1

As TENM3-AS1 functions in neurons, it interacts with neuron-specific proteins that are critical for neuron survival and repair. TENM3-AS1 affects the repair and regeneration of neurons after injury by binding to these proteins. Overexpression and deletion of TENM3-AS1 leads to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases.

3. Pathological mechanism of TENM3-AS1

The pathological mechanism of TENM3-AS1 is unclear. However, studies have shown that overexpression and deletion of TENM3-AS1 can lead to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases. The gene expression level of TENM3-AS1 is positively correlated with the degree of neuronal damage, and the loss of TENM3-AS1 will lead to an increase in the degree of neuronal damage. In addition, TENM3-AS1 gene expression levels have been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Alzheimer's disease-related cerebellar ataxia.

4. The potential of TENM3-AS1 as a drug target or biomarker

TENM3-AS1, as a drug target or biomarker, has important value in the research and treatment of neurodegenerative diseases. Overexpression and deletion of TENM3-AS1 leads to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases. In addition, the association of TENM3-AS1 with neurodegenerative diseases also suggests that it may be a potential drug target or biomarker. In the future, researchers can conduct experiments using TENM3-AS1 as a therapeutic target or biomarker for neurodegenerative diseases to evaluate its clinical value.

5 Conclusion

TENM3-AS1 is an RNA chaperone that functions in neurons. Overexpression and deletion of TENM3-AS1 leads to neuronal damage and synaptic variability, thereby increasing the risk of neurodegenerative diseases. In addition, the association of TENM3-AS1 with neurodegenerative diseases also suggests that it may be a potential drug target or biomarker. In the future, TENM3-AS1 can be experimented as a therapeutic target or biomarker for neurodegenerative diseases to evaluate its clinical value.

Protein Name: TENM3 Antisense RNA 1

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