REEP6: A Protein Target for Drug and Biomarker Development (G92840)

Target Name: REEP6

NCBI ID: G92840

REEP6: A Protein Target for Drug and Biomarker Development

REEP6 (RE-6-Endoplasmic Reticulum-Proximals) is a protein that is expressed in various tissues throughout the body. It is a key regulator of protein synthesis and degradation, and is involved in the turnover of proteins in the endoplasmic reticulum (ER).

One of the unique features of REEP6 is its ability to interact with small molecules, such as drugs that are designed to modulate protein function. This makes REEP6 an attractive target for drug development, as it allows researchers to develop new treatments for a variety of diseases.

REEP6 functions as a negative regulator of the ribosome, which is the machine that synthesizes proteins in the cell. It does this by interacting with the protein known as p23, which is a key component of the ribosome.

REEP6 helps to regulate the activity of the ribosome by influencing the formation of a complex between the protein and the RNA polymerase II. This complex is known as the P-p23-REEP6 complex, and it is formed when the ribosome is translated from mRNA.

Once the ribosome has been translated, the P-p23-REEP6 complex is disassembled, and the free RNA polymerase II is able to interact with the newly synthesized protein. This allows the protein to be processed and degraded in the ER, where it is no longer needed.

The importance of REEP6 as a drug target is that it allows researchers to develop new treatments for a variety of diseases. For example, REEP6 has been shown to be involved in the regulation of cell growth, and is often used as a target for anti- cancer drugs.

In addition to its potential as a drug target, REEP6 is also a potential biomarker for certain diseases. For example, it has been shown to be elevated in the blood of patients with certain types of cancer, which could be used as a diagnostic marker.

Overall, REEP6 is a promising target for drug development, and its role as a biomarker for certain diseases makes it an important player in the field of pharmacology. Further research is needed to fully understand the function of REEP6 and its potential as a drug and biomarker .

Protein Name: Receptor Accessory Protein 6

Functions: Required for correct function and survival of retinal photoreceptors (PubMed:27889058). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity)

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