HOMER3: A Protein Implicated in Cell Division and Disease (G9454)

Target Name: HOMER3

NCBI ID: G9454

HOMER3: A Protein Implicated in Cell Division and Disease

Homolog 3 (HOMER3) is a gene that encodes a protein known as the Homolog 3 protein. The Homolog 3 protein is a key regulator of cell division and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

HOMER3 is a member of the Homolog 3 family of proteins, which are characterized by a conserved catalytic core and a unique N-terminal region that includes a nucleotide-binding oligomerization (NBO) domain. The NBO domain is a common feature of proteins that regulate DNA replication and transcription, and is thought to play a role in the regulation of cell growth and division.

One of the unique features of HOMER3 is its ability to interact with DNA in a highly specific and efficient manner. Studies have shown that HOMER3 can form a stable complex with DNA in a cell-free state, and that this interaction is critical for the regulation of DNA replication and transcription.

In addition to its role in regulating DNA replication, HOMER3 is also involved in the regulation of cell growth and differentiation. Studies have shown that HOMER3 can inhibit the growth of cancer cells and that this inhibition is enhanced in cells that have been treated with the drug doxorubicin.

Another promising aspect of HOMER3 is its potential as a drug target. Studies have shown that HOMER3 is a promising target for small molecule inhibitors, including those that target the NBO domain. In addition, HOMER3 has been shown to be involved in a number of cellular processes that are important for cancer progression, including the regulation of cell adhesion, migration, and invasion.

Overall, HOMER3 is a protein that has significant potential as a drug target or biomarker. Further research is needed to fully understand its role in the regulation of cell division and growth, and to develop effective treatments for the diseases associated with its dysfunction.

Protein Name: Homer Scaffold Protein 3

Functions: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)

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