Target Name: HPGD
NCBI ID: G3248
Other Name(s): Short chain dehydrogenase/reductase family 36C member 1 | 15-Hydroxyprostanoic dehydrogenase | HPGD variant 1 | 15-hydroxyprostaglandin dehydrogenase | PGDH | PGDH_HUMAN | PGDH1 | short chain dehydrogenase/reductase family 36C member 1 | 15-PGDH | Hydroxyprostaglandin dehydrogenase 15-(NAD) | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I) | PHOAR1 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (isoform 1) | 15-hydroxyprostaglandin dehydrogenase, transcript variant 1 | Prostaglandin dehydrogenase | Short chain dehydrogenase/reductase family 36C, member 1 | 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | prostaglandin dehydrogenase 1 | SDR36C1 | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | 15-OH-PGDH | Eicosanoid/docosanoid dehydrogenase [NAD(+)] | 15-hydroxyprostaglandin dehydrogenase (NAD) | 15-hydroxyprostaglandin dehydrogenase (NAD(+)) | NAD-specific 15-hydroxyprostaglandin dehydrogenase | hydroxyprostaglandin dehydrogenase 15-(NAD) | Prostaglandin dehydrogenase 1 | eicosanoid/docosanoid dehydrogenase

HPGD: Key Enzyme in Plant Plastidial Electron Transport Chain

Hetero-Plastidium Generator (HPGD) is a protein that belongs to the Short Chain Dehydrogenase/Reductase Family 36C. It is a key enzyme in the plastidial electron transport chain, which is a critical pathway for energy production in plant cells. HPGD is responsible for

Protein Name: 15-hydroxyprostaglandin Dehydrogenase

Functions: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, PubMed:10837478, PubMed:16828555, PubMed:16757471, PubMed:21916491, PubMed:25586183). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, PubMed:15574495). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113)

More Common Targets

HPGDS | HPN | HPN-AS1 | HPR | HPRT1 | HPRT1P2 | HPS1 | HPS3 | HPS4 | HPS5 | HPS6 | HPSE | HPSE2 | HPX | HPYR1 | HR | HRAS | HRC | HRCT1 | HRG | HRH1 | HRH2 | HRH3 | HRH4 | HRK | HRNR | HROB | HS1BP3 | HS1BP3-IT1 | HS2ST1 | HS3ST1 | HS3ST2 | HS3ST3A1 | HS3ST3B1 | HS3ST4 | HS3ST5 | HS3ST6 | HS6ST1 | HS6ST2 | HS6ST3 | HSBP1 | HSBP1L1 | HSCB | HSD11B1 | HSD11B1-AS1 | HSD11B1L | HSD11B2 | HSD17B1 | HSD17B1-AS1 | HSD17B10 | HSD17B11 | HSD17B12 | HSD17B13 | HSD17B14 | HSD17B1P1 | HSD17B2 | HSD17B3 | HSD17B4 | HSD17B6 | HSD17B7 | HSD17B7P1 | HSD17B7P2 | HSD17B8 | HSD3B1 | HSD3B2 | HSD3B7 | HSD3BP4 | HSD3BP5 | HSD52 | HSDL1 | HSDL2 | HSDL2-AS1 | HSF1 | HSF2 | HSF2BP | HSF4 | HSF5 | HSFX1 | HSFX2 | HSFX3 | HSFY1 | HSFY1P1 | HSFY2 | HSH2D | HSP90AA1 | HSP90AA2P | HSP90AA3P | HSP90AA4P | HSP90AA5P | HSP90AA6P | HSP90AB1 | HSP90AB2P | HSP90AB3P | HSP90AB4P | HSP90B1 | HSP90B2P | HSP90B3P | HSPA12A | HSPA12B | HSPA13