HS2ST1: A Potential Drug Target and Biomarker (G9653)

Target Name: HS2ST1

NCBI ID: G9653

HS2ST1: A Potential Drug Target and Biomarker

Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is a gene that encodes a protein located in the endoplasmic reticulum (ER) of the cell. HS2ST1 plays a crucial role in the biosynthesis of heparan sulfate, which is a major component of extracellular matrix (ECM) components such as collagen and chondroitin. ECM components are vital for cell-cell and cell-extracellular matrix interactions, which are essential for various physiological processes, including tissue repair, regeneration, and embryonic development.

HS2ST1 is a member of the superfamily of cysteine-endopeptidases (Ceph), which are a group of enzymes involved in the removal of peptidyl groups from proteins. These enzymes are of great interest in drug development because they can be used as drug targets or biomarkers. By inhibiting HS2ST1, researchers can potentially develop new treatments for various diseases.

One of the key challenges in drug development is identifying potential drug targets. A drug target is a protein or a molecule that is involved in a specific physiological process and can be targeted by small molecules or antibodies to disrupt that process. In the case of HS2ST1, researchers are interested in studying its potential as a drug target because of its involvement in ECM synthesis and because it is a cytoplasmic protein that is expressed in a variety of tissues.

HS2ST1 functions as the rate limiting step in the biosynthesis of heparan sulfate from the starting amino acid glutamic acid. It is a transmembrane protein that is expressed in various tissues, including the liver, heart, and kidneys. It is also a good candidate for a biomarker because its expression is often affected by diseases, such as diabetes, cancer, and neurodegenerative diseases.

In addition to its potential as a drug target, HS2ST1 is also a biomarker that can be used to diagnose and monitor various diseases. For example, the levels of HS2ST1 have been decreased in various diseases, including diabetes, cancer, and neurodegenerative diseases. This suggests that HS2ST1 may be a useful biomarker for these diseases.

Another potential application of HS2ST1 is its role in tissue repair and regeneration. Heparan sulfate is a key component of the extracellular matrix, which is critical for tissue repair and regeneration. By inhibiting HS2ST1, researchers may be able to develop new treatments for diseases that are characterized by poor tissue repair and regeneration, such as cancer and neurodegenerative diseases.

In conclusion, HS2ST1 is a gene that encodes a protein involved in the biosynthesis of heparan sulfate, which is a major component of ECM. As a result, it is a potential drug target and biomarker that can be used to develop new treatments for various diseases. Further research is needed to fully understand the role of HS2ST1 in the biosynthesis of heparan sulfate and its potential as a drug target and biomarker.

Protein Name: Heparan Sulfate 2-O-sulfotransferase 1

Functions: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity)

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