SEPTIN7: A Potential Drug Target and Biomarker (G989)

Target Name: SEPTIN7

NCBI ID: G989

SEPTIN7: A Potential Drug Target and Biomarker

SEPTIN7 is a gene that encodes a protein known as SEPIN7. It is a member of the SEPIN family, which is characterized by the presence of a unique N-terminal domain called N-SEPIN. SEPIN7 is expressed in various tissues and cells throughout the body, including epithelial, endothelial, and nervous cells. It plays a critical role in cell signaling, particularly in the regulation of cell adhesion and migration.

SEPIN7 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The N-SEPIN domain of SEPIN7 has been shown to interact with various signaling molecules, including TGF-β, Wnt, and Notch. These interactions suggest that SEPIN7 may be a regulator of cellular signaling pathways that are involved in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In addition to its potential as a drug target, SEPIN7 has also been identified as a biomarker for several diseases. For example, SEPIN7 has been shown to be downregulated in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that levels of SEPIN7 may be a useful biomarker for these cancers. Additionally, SEPIN7 has been shown to be involved in the regulation of cellular processes that are important for brain development and function, including the regulation of neuronal migration and synaptic plasticity. This suggests that SEPIN7 may be a useful biomarker for neurological disorders, such as Alzheimer's disease and Parkinson's disease.

SEPIN7 has also been shown to be involved in the regulation of cellular processes that are important for eye development and function. This suggests that SEPIN7 may be a useful biomarker for diseases of the eye, such as age-related macular degeneration and cataracts.

In conclusion, SEPIN7 is a gene that has been identified as a potential drug target and biomarker. The N-SEPIN domain of SEPIN7 has been shown to interact with various signaling molecules, suggesting that it may be involved in the regulation of cellular signaling pathways that are important for a variety of diseases. Further research is needed to confirm these findings and to determine the full scope of SEPIN7's role in cellular processes.

Protein Name: Septin 7

Functions: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830)

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