TNK2: A Potential Drug Target and Biomarker for Diseases (G10188)

Target Name: TNK2

NCBI ID: G10188

TNK2: A Potential Drug Target and Biomarker for Diseases

TNK2, also known as Activated CDC42 Kinase 1 (ISOFORM 1), is a protein that is expressed in various tissues throughout the body. It plays a crucial role in cell signaling and is involved in a wide range of physiological processes.tnk2 has been identified as a potential drug target and has been shown to have a positive impact on various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TNK2 signaling pathway

TNK2 is a protein that is involved in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is responsible for promoting cell growth, differentiation, and survival. The TGF-β pathway is a complex signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. It is composed of several transcription factors, including SMAD, TGF-β1, and TNK2.

TNK2 is a key transcription factor that is involved in the regulation of TGF-β signaling pathway. It plays a crucial role in the regulation of cell proliferation and differentiation by promoting the expression of genes that are involved in cell growth and survival. TNK2 has been shown to promote the expression of genes that are involved in the regulation of cell cycle, cell adhesion, and angiogenesis.

In addition to its role in the TGF-β pathway, TNK2 is also involved in the regulation of several other signaling pathways, including the PI3K/Akt signaling pathway and the NF-kappa-B signaling pathway. These pathways are involved in the regulation of cell survival, differentiation, and inflammation.

TNK2 as a drug target

TNK2 has been identified as a potential drug target due to its involvement in several diseases. The TGF-β pathway is involved in the regulation of cell growth and development, and dysregulation of this pathway has been implicated in the development of a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

TNK2 has been shown to promote the growth and survival of cancer cells, and it has been shown to play a role in the regulation of cancer cell stemness. TNK2 has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its role in cancer and neurodegenerative diseases, TNK2 has also been implicated in the development of autoimmune disorders. Autoimmune disorders are characterized by the production of antibodies that target the body's own tissues and can result in inflammation, autoimmune diseases, and other disorders.

TNK2 has been shown to be involved in the regulation of autoimmune disorders by promoting the production of antibodies and promoting the recruitment of immune cells to the site of inflammation.

TNK2 as a biomarker

TNK2 has also been identified as a potential biomarker for several diseases. The TGF-β pathway is involved in the regulation of cell growth and development, and dysregulation of this pathway has been implicated in the development of a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

TNK2 has been shown to be involved in the regulation of cell growth and development, and it has been shown to play a role in the regulation of cancer cell stemness. TNK2 has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its role in cancer and neurodegenerative diseases, TNK2 has also been implicated in the development of autoimmune disorders. Autoimmune disorders are characterized by the production of antibodies that target the body's own tissues and can result in inflammation, autoimmune diseases, and other disorders.

TNK2 has been shown to be involved in the regulation of autoimmune disorders by promoting the production of antibodies and promoting the recruitment of immune cells to the site of inflammation.

Conclusion

TNK2 is a protein that is involved in the regulation of cell signaling pathways, including the TGF-β pathway. It has been shown to promote the growth and survival of cancer cells and to play a role in the regulation of cancer cell stemness, neurodegenerative diseases, and autoimmune disorders. As a result, TNK2 has

Protein Name: Tyrosine Kinase Non Receptor 2

Functions: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370)

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