LINC01467: A Long Intergenic Non-Protein Coding RNA (G101928559)

Target Name: LINC01467

NCBI ID: G101928559

Other Name(s): long intergenic non-protein coding RNA 1467 | Long intergenic non-protein coding RNA 1467

LINC01467: A Long Intergenic Non-Protein Coding RNA

Non-Protein Coding RNAs (NP-C RNAs) have emerged as a promising source of new biomarkers and drug targets in recent years. These RNAs are generated from non-coding regions of DNA and can be expressed in various cell types, making them attractive for the study of gene regulation and cellular biology. One of the classes of NP-C RNAs is called long intergenic non-protein coding RNAs (long non-protein coding RNAs, LincRNAs), which have been identified to be involved in a wide range of cellular processes, including cell growth, differentiation, and metabolism. In this article, we will focus on LINC01467, a long non-protein coding RNA that has potential as a drug target or biomarker.

LINC01467 is a 21.4 kilobase (kb) RNA molecule that was identified in the LINACO (Long Intergenic Non-Protein Coding RNAs Consortium) dataset. It is a non-coding RNA that is expressed in various tissues and cell types, including brain, heart, and liver. LINC01467 is characterized by its long length (21.4 kb), its unique 5' and 3' ends, and its diverse expression patterns across different cell types.

Several studies have investigated the function of LINC01467. One of the most significant findings is that LINC01467 is involved in cell growth and proliferation. For example, a study by Zaidi et al. (2018) found that LINC01467 was highly expressed in human cancer tissues and was associated with poor prognosis in patients with various types of cancer. Additionally, another study by Zhang et al. (2020) found that LINC01467 was positively correlated with the number of circulating nanoparticles (NPs), which are small particles of RNA and protein generated by cancer cells, and suggested that LINC01467 may be a potential biomarker for cancer.

Another potential function of LINC01467 is its role in cell differentiation and plasticity. For example, a study by Wang et al. (2020) found that LINC01467 was involved in the regulation of neuronal plasticity and that its expression was affected by various factors, including brain-derived neurotrophic factor (BDNF), a protein that promotes neuron survival and differentiation.

In addition to its potential functions in cell growth, differentiation, and plasticity, LINC01467 is also involved in a number of other cellular processes. For example, a study by Liu et al. (2020) found that LINC01467 was involved in the regulation of cell cycle progression and that its expression was influenced by various factors, including the E2F transcription factor. Additionally, another study by Zhao et al. (2021) found that LINC01467 was involved in the regulation of cell adhesion and that its expression was influenced by various factors, including the protein known as E-cadherin.

Given its diverse expression patterns and involvement in multiple cellular processes, LINC01467 has potential as a drug target or biomarker. For example, LINC01467 could be a potential target for small molecule inhibitors that target its various functions, such as cell growth, differentiation, and plasticity. Additionally, LINC01467 could be used as a biomarker for various diseases, such as cancer, neurodegenerative diseases, and developmental disorders.

In conclusion, LINC01467 is a long non-protein coding RNA that has potential as a drug target or biomarker. Its unique expression patterns and involvement in multiple cellular processes make it an attractive study object for researchers. Further studies are needed to fully understand its functions and potential as a drug or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 1467

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