Understanding The Role of CLPX in The Immune System (G10845)

Target Name: CLPX

NCBI ID: G10845

Understanding The Role of CLPX in The Immune System

CLPX (Complement component C5), also known as EPP2, is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and skeletal muscles. It is a key component of the complement system, which is a group of proteins that work together to help the immune system fight off infections.

One of the functions of CLPX is to help regulate the activity of the complement system. This is important because when the complement system is activated, it can cause a number of different health problems, including anaphylaxis, a severe allergic reaction. By helping to regulate the activity of the complement system, CLPX may help to reduce the risk of these types of reactions.

Another function of CLPX is to help promote the growth and development of new tissues. This is important because many diseases, including cancer, start with the development of new cells that can grow out of control. By promoting the growth and development of these cells, CLPX may help to contribute to the development and progression of these diseases.

In addition to its role in regulating the complement system and promoting tissue growth, CLPX is also thought to have a number of potential drug-related targets. For example, some studies have suggested that CLPX may be a good candidate for targeting with drugs that are designed to inhibit the activity of the complement system. This could be useful for treating a number of different diseases, including cancer, autoimmune disorders, and infections.

Another potential use for CLPX is as a biomarker for certain types of cancer. Some studies have suggested that the levels of CLPX in certain types of cancer cells may be a useful indicator of the severity of the disease. This could be a promising approach for diagnosing and monitoring the progress of these types of diseases.

Overall, CLPX is a protein that is involved in a number of important functions in the body. It is also a potential drug target and biomarker, with potential applications in the treatment of a wide range of diseases. Further research is needed to fully understand the role of CLPX in the immune system and the development of new tissues, as well as its potential as a drug and biomarker.

Protein Name: Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X

Functions: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through up-regulation of heme biosynthesis (PubMed:25957689, PubMed:28874591)

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