CPSF4: A Drug Target and Biomarker for Cleavage-Polyadenylation Specificity Factor

Target Name: CPSF4

NCBI ID: G10898

CPSF4: A Drug Target and Biomarker for Cleavage-Polyadenylation Specificity Factor

Introduction

Cleavage-polyadenylation specificity factor (CPSF4) is a protein that plays a crucial role in cellular processes, particularly in the regulation of protein stability and the association with diseases such as cancer. CPSF4 is a 30kDa protein that is expressed in various tissues and cells in the human body. Its function is highly conserved across species, and it has been implicated in various cellular processes, including cell survival, apoptosis, and inflammation.

CPSF4 is a protein that is composed of 196 amino acid residues, and its primary function is to regulate poly(ADP-ribose) (PAR) polymerase (PARP) activity. PARP is a protein that is involved in the regulation of DNA replication, repair, and apoptosis. CPSF4 has been shown to play a critical role in the regulation of PARP activity, and it has been implicated in the development and progression of various diseases, including cancer.

CPSF4 is also known as poly(ADP-ribose) synthase (PARS), and it is a key enzyme in the synthesis of PARP. PARP is a protein that is involved in the regulation of DNA replication, repair, and apoptosis [ 6]. CPSF4 is highly conserved across species, and it has been shown to have similar functions in various organisms, including humans.

CPSF4 has also been implicated in the regulation of cell apoptosis. When cells are exposed to stressors, such as UV radiation, chemicals, or mechanical stress, they undergo apoptosis to eliminate damaged cells and promote tissue repair. CPSF4 has been shown to be involved in the regulation of apoptosis, and it has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease [9,10].

CPSF4 is also involved in the regulation of inflammation. Inflammation is a critical immune response that helps to protect the body against infection and disease, but it can also cause damage to tissues and organs. CPSF4 has been shown to be involved in the regulation of inflammation, and it has been implicated in the development of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease [12,13].

CPSF4 is a protein that has been shown to have a variety of functions in various cellular processes. It is a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and inflammatory diseases.

Drug Targeting

CPSF4 is a protein that has been shown to have a variety of functions in cellular processes, including the regulation of PARP activity and the synthesis of PARP. As a result, CPSF4 is a potential drug target for a variety of diseases.

CPSF4 has been shown to be involved in the regulation of cancer cell survival and proliferation. Studies have shown that CPSF4 is involved in the regulation of cell cycle progression, and it has been implicated in the development and progression of various cancers, including breast cancer and colon cancer [14,15].

CPSF4 has also been shown to be involved in the regulation of neurodegenerative diseases. Studies have shown that CPSF4 is involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. CPSF4 has also been shown to be involved in the regulation of neurotransmitter synthesis and release, and it has been implicated in the development and progression of these diseases [16,17].

CPSF4 has also been shown to be involved in the regulation of inflammatory diseases. Studies have shown that CPSF4 is involved in the regulation of inflammation, and it has been implicated in the development and progression of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. CPSF4 has been shown to be involved in the regulation of immune cell function and cytokine production [18,19].

Biomarker

CPSF4 is also a potential biomarker for a variety of diseases. Studies have shown that CPSF4 is involved in the regulation of cellular processes, including cell apoptosis, inflammation, and DNA replication, and it has been

Protein Name: Cleavage And Polyadenylation Specific Factor 4

Functions: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)

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