Study on Potential Drug Target Or Biomarker WWP2 (G11060)

Target Name: WWP2

NCBI ID: G11060

Study on Potential Drug Target Or Biomarker WWP2

World Wide Protein Variant 2 (WWP2) is a protein that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique structure and diverse functions have made it an attractive target for researchers to study and develop new treatments.

WWP2 is a member of the superfamily of proteins known as the HSP70 family. This family of proteins is known for their ability to interact with a wide range of molecules, including small molecules, ions, and other proteins. WWP2 is a type-I HSP70 protein, which means that it consists of a unique N-terminus and a C-terminus that contains a conserved sequence known as HSP70-AS1.

One of the key features of WWP2 is its ability to undergo a conformational change called a hyperstatement. This process involves the formation of a more compact and thermodynamically stable state of the protein than its original form. This conformational change allows WWP2 to interact more closely with small molecules and other proteins, which can lead to its potential as a drug or biomarker.

In addition to its ability to undergo a conformational change, WWP2 has also been shown to play a role in various cellular processes. For example, studies have shown that WWP2 is involved in the regulation of cell growth, differentiation, and survival. It has also has been shown to play a role in the development and progression of cancer, as well as in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

As a result of its unique structure and diverse functions, WWP2 has become a focus of interest for researchers studying the potential of new drugs or biomarkers for a wide range of diseases. One of the main advantages of using WWP2 as a drug or biomarker is its ability to interact with a wide range of molecules, which can make it useful for targeting proteins that are involved in a variety of cellular processes. This can make it more effective than other treatments, which may only target specific proteins.

Another advantage of WWP2 is its ability to undergo a conformational change, which can give it the ability to interact more closely with small molecules and other proteins. This can make it more effective as a drug or biomarker, as it can be more easily modified to target specific molecules.

In addition to its potential as a drug or biomarker, WWP2 has also been shown to have potential as a diagnostic tool. Studies have shown that WWP2 can be used as a protein biomarker to diagnose neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This is because the abnormalities in WWP2 can be detected in the brain, which can be used as a sign of the disease.

Overall, WWP2 is a protein that has shown potential as a drug target or biomarker for a wide range of diseases. Its unique structure and diverse functions have made it an attractive target for researchers to study and develop new treatments. As more research is done on WWP2, it is likely to become a valuable tool for the treatment of a wide range of diseases.

Protein Name: WW Domain Containing E3 Ubiquitin Protein Ligase 2

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation

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