CKB: A Protein Crucial for Cell Growth and Development (G1152)

Target Name: CKB

NCBI ID: G1152

CKB: A Protein Crucial for Cell Growth and Development

CKB (B-CK) is a protein that is expressed in various tissues throughout the body, including the brain, heart, lungs, and kidneys. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and supports their growth and movement.

Recent studies have identified CKB as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because CKB plays a role in the regulation of many cellular processes that are important for normal tissue growth and function, and abnormal regulation of these processes can contribute to the development and progression of these diseases.

One of the key functions of CKB is its role in the regulation of cell division. CKB is a critical regulator of the G1/S checkpoint, a critical step in the cell cycle that ensures that cells divide and grow in a controlled and orderly manner. During the G1 phase, CKB helps to ensure that the cell has enough reason to enter the S phase and begin cell division. And during the S phase, CKB helps to ensure that the cell divides correctly and that the new cell that is created is identical to the original cell.

Another important function of CKB is its role in the regulation of cell death. CKB is a key regulator of cell death, and it is involved in the process of apoptosis, which is a natural and important mechanism for eliminating damaged or dysfunctional cells. During apoptosis , CKB helps to ensure that the cell undergoes proper degradation and disposal, and that the process is not errors or mutations that could cause the cell to continue to divide and survive.

In addition to its role in cell division and cell death, CKB is also involved in the regulation of many other cellular processes that are important for normal tissue growth and function. For example, CKB is involved in the regulation of cell migration, which is the movement of cells from the place where they were born to their final destinations in the body. It is also involved in the regulation of the production of new blood vessels, which is important for delivering oxygen and nutrients to tissues and organs.

Despite its importance for many cellular processes, CKB is not well understood, and there are many questions that need to be answered about its role in the development and progression of diseases. For example, it is not clear why some people with neurodegenerative diseases, such as Alzheimer's and Parkinson's, have increased levels of CKB, while others do not. It is also not clear why certain drugs, such as those used to treat cancer, may be able to inhibit the activity of CKB.

In conclusion, CKB is a protein that plays a critical role in the regulation of many cellular processes that are important for normal tissue growth and function. Its regulation of cell division, cell death, and cell migration is crucial for the development and progression of many diseases. Further research is needed to better understand the role of CKB in diseases, including the development and progression of cancer and neurodegenerative diseases.

Protein Name: Creatine Kinase B

Functions: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)

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