CLEC4C: A Drug Target / Disease Biomarker (G170482)

Target Name: CLEC4C

NCBI ID: G170482

CLEC4C: A Drug Target / Disease Biomarker

CLEC4C, also known as G protein-coupled receptor 4C, is a protein that is expressed in various tissues throughout the body. It is a member of the G protein-coupled receptor family, which is a large family of transmembrane proteins that play an important role in cellular signaling. G protein-coupled receptors are involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and hormone regulation.

One of the key functions of G protein-coupled receptors is to transmit signals from the cell surface to the intracellular signaling pathway. When a G protein-coupled receptor is activated, it sends a signal to the intracellular signaling pathway, which then triggers a series of downstream signaling pathways that ultimately result in the production of a specific protein or the modification of a particular protein.

CLEC4C is a protein that is expressed in various tissues throughout the body, including the brain, heart, and peripheral tissues. It is involved in a wide range of physiological processes, including neurotransmitter signaling, pain perception, and hormone regulation.

One of the key functions of CLEC4C is its role in neurotransmitter signaling. CLEC4C is involved in the regulation of neurotransmitter release from neurons, which is critical for the transmission of signals in the nervous system. clec4c-/- mice have reduced neurotransmitter release and increased sensitivity to neurotransmitter agonists, suggesting a role for clec4c in neurotransmitter signaling.

CLEC4C is also involved in pain perception. clec4c-/- mice have reduced pain sensitivity and an increased ability to escape from painful stimuli, suggesting a role for clec4c in modulating pain sensitivity.

CLEC4C is also involved in hormone regulation. clec4c-/- mice have reduced insulin sensitivity and increased sensitivity to androgens, suggesting a role for clec4c in modulating hormone regulation.

CLEC4C is a protein that is involved in a wide range of physiological processes. Its function in neurotransmitter signaling, pain perception, and hormone regulation makes it an attractive drug target. Further research is needed to fully understand the role of clec4c in these processes and to develop effective therapies based on clec4c.

Protein Name: C-type Lectin Domain Family 4 Member C

Functions: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283)

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