NUS1: A Protein Potential Drug Target Or Biomarker (G116150)

Target Name: NUS1

NCBI ID: G116150

NUS1: A Protein Potential Drug Target Or Biomarker

NUS1 (N-acetyl-L-tryptophan-2-carboxylic acid), also known as NgBR, is a protein that is expressed in various tissues and cells in the body. It is a key player in the regulation of cell growth, differentiation, and metabolism, and has been identified as a potential drug target or biomarker.

The NUS1 protein is composed of 214 amino acid residues and has a calculated molecular mass of 34.1 kDa. It is located in the cytoplasm and is primarily expressed in the osteoclast, a type of cell that is involved in bone resorption and formation. NUS1 is also expressed in other tissues, including the brain, heart, liver, and intestine.

NUS1 is involved in the regulation of several cellular processes that are critical for cell growth and development. One of its most well-studied functions is its role in cell proliferation. NUS1 has been shown to promote the growth and proliferation of various cell types, including osteoclasts, by increasing the levels of the protein tyrosine kinase (TK) in these cells.

NUS1 has also been shown to play a role in the regulation of cell differentiation and plasticity. It has been shown to promote the transformation of stem cells into functional brain cells, such as neurons, and has been shown to regulate the activity of genes involved in cell differentiation and plasticity.

In addition to its role in cell proliferation and differentiation, NUS1 has also been shown to play a role in the regulation of cellular metabolism. It has been shown to play a role in the metabolism of nutrients, including glucose and fatty acids, and has been shown to regulate the levels of these nutrients in the cells.

NUS1 has also been shown to be involved in the regulation of cellular immune responses. It has been shown to play a role in the regulation of the production of antibodies by B cells and has been shown to promote the activation and proliferation of these cells in response to foreign substances in the body.

Despite its potential as a drug target or biomarker, NUS1 has yet to be fully characterized and its functions have not been fully understood. Further research is needed to fully determine the role of NUS1 in cellular processes and to develop better treatments for various diseases.

In conclusion, NUS1 is a protein that is expressed in various tissues and cells in the body and is involved in several cellular processes that are critical for cell growth, development, and metabolism. Its functions have been well-studied, and it has been shown to have potential as a drug target or biomarker for various diseases. Further research is needed to fully understand its role and to develop better treatments.

Protein Name: NUS1 Dehydrodolichyl Diphosphate Synthase Subunit

Functions: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300)

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