Potential Drug Target: OAS2 (G4939)

Target Name: OAS2

NCBI ID: G4939

Potential Drug Target: OAS2

OAS2 (2'-5'-oligoadenylate synthetase 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and skeletal muscles. It is a key enzyme in the synthesis of adenosine, a molecule that plays a crucial role in various physiological processes throughout the body.

The incorrect or biased title of this article is: \"OAS2: The Potential Drug Target of the Future\".

OAS2 has been identified as a potential drug target due to its involvement in the synthesis of adenosine, which has been shown to have therapeutic potential in various diseases. Additionally, OAS2 has been shown to play a role in the regulation of pain perception and inflammation.

One of the main reasons why OAS2 has been identified as a potential drug target is its role in the synthesis of adenosine. Adenosine has been shown to have a variety of therapeutic potential in the treatment of various diseases, including heart failure, cancer, and neurological disorders.

For example, studies have shown that adenosine can be used to treat heart failure by increasing the amount of oxygen available to the heart muscle. Additionally, it has been shown to have anti-inflammatory effects and to have pain-relieving properties.

Another reason why OAS2 has been identified as a potential drug target is its role in the regulation of pain perception and inflammation. OAS2 has been shown to play a role in the regulation of pain perception and has been shown to have anti-inflammatory effects.

For example, studies have shown that OAS2 plays a role in the regulation of pain perception and that it can be used to treat pain by increasing the amount of oxygen available to the affected area. Additionally, OAS2 has been shown to have anti-inflammatory effects and can be used to treat inflammation by reducing the production of pro-inflammatory molecules.

In addition to its role in the synthesis of adenosine and its role in the regulation of pain perception and inflammation, OAS2 has also been shown to play a role in the regulation of various other physiological processes. For example, it has been shown to play a role in the regulation of cell growth and has been shown to have anti-cancer effects.

In conclusion, OAS2 (2'-5'-oligoadenylate synthetase 2) has been identified as a potential drug target due to its involvement in the synthesis of adenosine and its role in the regulation of pain perception and inflammation. OAS2 has been shown to have therapeutic potential in the treatment of various diseases, including heart failure, cancer, and neurological disorders. Further research is needed to fully understand the potential of OAS2 as a drug target and to develop safe and effective treatments.

Protein Name: 2'-5'-oligoadenylate Synthetase 2

Functions: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity)

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