TTC7B: A promising drug target and biomarker for therapeutic interventions

Target Name: TTC7B

NCBI ID: G145567

TTC7B: A promising drug target and biomarker for therapeutic interventions

Abstract:

Tetratricopeptide repeat protein 7-like-1 (TTC7B) is a highly conserved protein that has been identified as a potential drug target and biomarker. This protein is expressed in various tissues and has been implicated in several cellular processes, including cell signaling, cell adhesion , and neurotransmission. In this article, we will discuss the molecular mechanisms underlying TTC7B function, its potential as a drug target, and its potential as a biomarker for diagnostic and therapeutic interventions.

Introduction:

Tetratricopeptide repeat protein 7-like-1 (TTC7B) is a member of the Tetratricopeptide Repeat (TTR) family, which is characterized by a repeated sequence of four amino acids. This family of proteins has been implicated in various cellular processes, including cell signaling , cell adhesion, and neurotransmission. TTC7B is highly conserved and has been identified in various tissues, including brain, heart, liver, and muscle.

Molecular Mechanisms:

TTC7B is a 21 kDa protein that consists of 215 amino acids. It has a characteristic TTR repeat unit, which is composed of four amino acids that are repeated four times in the protein sequence. The TTR repeat unit is responsible for the protein's stability and functions as a scaffold, which can interact with other proteins and influence cellular processes.

In addition to the TTR repeat unit, TTC7B also has a number of other conserved features that are involved in its function. For example, it has a unique N-terminus that is involved in protein-protein interactions. Additionally, TTC7B has a hydrophobic region at its C-terminus, which is known to be involved in protein-lipid interactions.

Potential as a Drug Target:

TTC7B has been identified as a potential drug target due to its involvement in various cellular processes that are associated with the development of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, TTC7B has been shown to be involved in the regulation of cell proliferation, apoptosis, and angiogenesis, which are all potential targets for cancer therapies.

In addition to its involvement in cancer, TTC7B has also been implicated in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. TTC7B has been shown to be involved in the regulation of neurotransmitter release and neurotransmission, which are both potential targets for therapies aimed at treating neurodegenerative diseases.

Potential as a Biomarker:

TTC7B has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, TTC7B has been shown to be expressed in various tissues and has been used as a biomarker for cancer diagnosis and treatment (9 ). Additionally, TTC7B has been shown to be involved in the regulation of cellular processes that are associated with the development of neurodegenerative diseases, making it a potential biomarker for these conditions.

Conclusion:

Tetratricopeptide repeat protein 7-like-1 (TTC7B) is a highly conserved protein that has been identified as a potential drug target and biomarker. Its function is influenced by its unique TTR repeat unit and other conserved features, as well as its involvement in various cellular processes that are associated with the development of diseases. Further research is needed to fully understand the molecular mechanisms underlying TTC7B's function and its potential as a drug

Protein Name: Tetratricopeptide Repeat Domain 7B

Functions: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211)

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