Unlocking the Potential of TUBA4A as a Drug Target and Biomarker

Target Name: TUBA4A

NCBI ID: G7277

Unlocking the Potential of TUBA4A as a Drug Target and Biomarker

Tubulin H2-alpha (TUBA4A) is a protein that plays a critical role in the structure and function of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. The cytoskeleton provides structural support, helps maintain cell shape, and plays a role in cell division and transport of organelles within the cell. TUBA4A is a key protein that helps maintain the stability and integrity of microtubules, which are crucial for many cellular processes.

Recent studies have identified TUBA4A as a potential drug target and biomarker. In this article, we will explore the biology of TUBA4A, its functions in microtubule dynamics, and its potential as a drug target.

The Biology of TUBA4A

TUBA4A is a 21-kDa protein that is expressed in most eukaryotic cells. It is a key component of the cytoskeleton and is involved in the stability and organization of microtubules. TUBA4A is composed of two distinct subunits, alpha- and beta-subunits, which are held together by a disulfide bond.

The alpha-subunit of TUBA4A contains a unique N-terminal region that is rich in acidic amino acids, which are important for the stability of the protein. The alpha-subunit also has a unique C-terminal region that is involved in the interaction with microtubule-associated protein 1 (MAP1), which is a protein that helps regulate microtubule dynamics.

The beta-subunit of TUBA4A is responsible for the interaction between the alpha- and beta-subunits. This interaction is critical for the stability and integrity of the microtubules.

TUBA4A's Functions in Microtubule Dynamics

TUBA4A plays a critical role in the stability and integrity of microtubules. It helps maintain the structural stability of microtubules by interacting with MAP1 and providing negative entropy to prevent the formation of disulfide bonds.

TUBA4A is also involved in regulating microtubule dynamics. It helps regulate the assembly and disassembly of microtubules and is involved in the regulation of microtubule-associated protein 2 (MAP2) levels, which are critical for the dynamics of microtubules.

TUBA4A's Potential as a Drug Target

TUBA4A's involvement in microtubule dynamics makes it an attractive drug target. The disruption of microtubule dynamics has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the potential drug targets for TUBA4A is the inhibition of microtubule-associated protein 1 (MAP1), which is a protein that helps regulate microtubule dynamics. Activated MAP1 has been shown to promote the assembly and maintenance of microtubules, while inhibited MAP1 has been shown to disrupt microtubule dynamics.

Another potential drug target for TUBA4A is the inhibition of microtubule-associated protein 2 (MAP2), which is a protein that is involved in the regulation of microtubule dynamics.MAP2 has been shown to play a critical role in the assembly and stability of microtubules, and inhibition of MAP2 has been shown to disrupt microtubule dynamics.

TUBA4A's Potential as a Biomarker

TUBA4A is also an attractive biomarker for the diagnosis and monitoring of various diseases. The disruption of microtubule dynamics has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the potential applications of TUBA4A as a biomarker is its ability to be used as a diagnostic marker for cancer. TUBA4A is often expressed in

Protein Name: Tubulin Alpha 4a

Functions: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

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