TUSC3: A Protein with Tissue-specific Expression and Unique Biology

Target Name: TUSC3

NCBI ID: G7991

TUSC3: A Protein with Tissue-specific Expression and Unique Biology

TUSC3 (Tissue-Specific uridylate-binding protein 3) is a protein that is expressed in various tissues of the human body, including the lungs, heart, kidneys, and intestines. It is a member of the uridylate-binding protein family, which is a family of transmembrane proteins that play a critical role in various physiological processes, including cellular signaling and waste elimination.

One of the unique features of TUSC3 is its tissue-specific expression. Unlike many other proteins, TUSC3 is not widely expressed in any particular tissue, but is instead expressed in a variety of tissues throughout the body. This makes it an attractive candidate for drug targeting, as it allows for the development of targeted therapies that can be specific to a particular tissue ororgan.

In addition to its tissue-specific expression, TUSC3 is also known for its unique biology. For example, TUSC3 is a protein that is primarily expressed in the lungs, and has been shown to play a critical role in the regulation of aerobic metabolism. Additionally , TUSC3 has been shown to be involved in the regulation of inflammation and fibrosis, which are important processes that can contribute to a variety of diseases, including cancer and cardiovascular disease.

These properties make TUSC3 an intriguing drug target, with potential applications in a variety of therapeutic areas. For example, TUSC3 could be targeted in the treatment of respiratory diseases, such as cancer, chronic obstructive pulmonary disease (COPD), and asthma. By inhibiting the activity of TUSC3, researchers could potentially improve lung function and reduce the risk of complications in these conditions.

In addition to its potential as a drug target, TUSC3 is also a potential biomarker. The regulation of TUSC3 expression has been shown to be involved in a variety of biological processes, including cellular signaling, waste elimination, and inflammation. This makes TUSC3 an attractive candidate for use as a biomarker for a variety of diseases. For example, TUSC3 has been shown to be involved in the regulation of cancer cell growth and metastasis, which could make it an attractive candidate for use as a biomarker for cancer.

In conclusion, TUSC3 is a protein that is expressed in various tissues of the human body, and has been shown to play a critical role in a variety of physiological processes. Its tissue-specific expression and unique biology make it an intriguing candidate for drug targeting and biomarker development. Further research is needed to fully understand the role of TUSC3 in various biological processes and its potential as a therapeutic target and biomarker.

Protein Name: Tumor Suppressor Candidate 3

Functions: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition

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