Graft-versus-host Disease
About the Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion
Common Targets / Biomarkers
CD74 | ICAM1 | Lysophospholipid (edg) Receptors (nonspecified subtype) | TRPV2 | LOC105375139 | FLT3 | ORAI1 | CD247 | LAG3 | C-C chemokine receptor (nonspecified subtype) | PPP3R2 | HDAC3 | DHODH | TNFRSF25 | SDAD1-AS1 | CD6 | DNA-Directed RNA Polymerase (nonspecified subtype) | NPM1 | SYK | DPP4 | PRMT5 | CCL5 | PPP3CC | BRD2 | TLR2 | Hedgehog Protein (nonspecified subtype) | BSG | NOD2 | GSK3B | GSTT1 | IL17A | CD40 | SELL | PTCH1 | SUFU | BMX | VKORC1 | IL-1 Receptor (nonspecified subtype) | CTLA4 | LOC728392 | PPID | LOC102724428 | DAAM2 | HLA-G | IL7R | CTPS1 | Integrin alpha4beta7 (LPAM-1) receptor | SERPINE1 | CD83 | ARG1 | TNFSF13B | CD38 | IL1RL1 | ATP Synthase, H+ Transporting, Mitochondrial F0 complex | JAK2 | PDGFRA | S1PR4 | KIT | CD86 | CCR7 | HSF1 | S1PR2 | SELP | IL-2 receptor | NFKBIA | TLR9 | DCK | RAF1 | ATP5IF1 | MASP2 | MS4A1 | HDAC11 | TRPA1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | IFNG | BRAF | CMC2 | IL34 | LOC105377795 | Interleukin-12 (IL-12) | IL2 | ITK | JAK3 | FGFR4 | ADA | TLR4 | NLRP3 | JAK1 | IL1A | S1PR3 | CYP3A5 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | IL10RB | IMPDH1 | Proteasome Complex | CRBN | Adenosine deaminase (nonspecified subtype) | NLRP3 Inflammasome | Histone deacetylase (nonspecified subtype) | FASLG | ITGA4 | SLC16A1 | CD48 | CCR5 | HLA-DPA1 | CD52 | ROCK2 | MTHFD2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | GSTM1 | MGMT | FCRL3 | Serine protease (nonspecified subtype) | PTGDR2 | TGFB1 | PECAM1 | PLAT | IL5 | CXCR3 | CD8 | AHR | BLK | PDCD1 | UGT1A9 | CD4 | IL4 | CYP1A2 | GLCCI1 | HLA-DQB1 | HDAC9 | ABL1 | PIM1 | CD80 | RFC1 | PTPN22 | SIK2 | MIR146A | AZIN1 | LHCGR | CD7 | BCL2 | FPR2 | Immunoproteasome | GPR55 | PPP3CB | IL6R | SELPLG | S1PR5 | ITLN1 | Integrin alphaLbeta2 (LFA-1) receptor | BRD3 | EDN1 | PPP3R1 | CSF2 | LOC105378206 | HLA-DPB1 | FAS | IL13 | STAT3 | HLA-C | FGFR2 | PDGFRB | STING1 | MTOR | AKR1A1 | UGT2B17 | ALK | HLA-DRB1 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | EZH2 | HMGB1 | CSF1R | DHFR | HAVCR2 | TCIRG1 | CD19 | ALB | SIK1 | S1PR1 | ABCB1 | TNFRSF4 | TLR7 | TNFRSF17 | BTLA | PRKCQ | LOC105374527 | HIF1A | CASP1 | Uncharacterized LOC105371833, transcript variant X2 | BTK | HPSE | Glutaminase (nonspecified subtype) | EGFR | CD28 | TGFBR2 | CXCL10 | REG3A | PSMB8 | MTHFR | IRAK1 | ELANE | GLP2R | IL18 | HDAC2 | HCAR2 | TNF | FUT2 | IL21 | IL23R | TLR6 | CYP1B1 | NFKB1 | ABO | LOC105378657 | HLA-B | Mitochondrial pyruvate carrier complex (MPC) | TNFRSF8 | BCL6 | IL1RN | AURKA | NR3C1 | PTPRC | CD79B | IL18R1 | LIG1 | FOXP3 | CD276 | AOC3 | MICA | CDK2 | CD3 Complex (T Cell Receptor Complex) | GSPT1 | LGALS1 | RORC | IL6 | RNF111 | TBK1 | CYP3A4 | FGFR3 | MADCAM1 | Protein Phosphatase 2B | ITPKB | THRA | TRPV1 | CCL24 | TYK2 | TLR8 | CD8A | IL12B | PPIA | PARP1 | TRPM8 | PIK3CD | THBD | VSIR | CYP2C19 | Protein kinase C (nonspecified subtype) | TLR1 | ACHE | SELE | SIK3 | IL2RB | INS | SDAD1 | SMO | HDAC1 | IL22RA1 | RIPK2 | Interleukin 17 (nonspecified subtype) | BRD4 | ABCG2 | C5 | VDR | APEH | IL1B | Interleukin-7 receptor | Alpha-2 Adrenergic receptors (nonspecified subtype) | KIR2DS4 | CAMKK2 | CXCL11 | INPP5D | FGFR1 | TNFSF4 | CD40LG | FKBP1A | IL2RA | GLCCI1-DT | GSK3A | Protein Phosphatase 2A | FCGR2B | ICOS | KCNA3 | NCR2 | Integrin alpha4beta1 (VLA-4) receptor | TRBC2 | KLRC1 | MALT1 | HMGCR | Folate Receptor (nonspecified subtype) | MAPK14 | HDAC10 | ART3 | ROCK1 | BCR | TEC | ATP synthase, H+ transporting, mitochondrial F1 complex | PADI4 | IL10 | STAT6 | DNASE1 | PSMB5 | IL-15 receptor | PF4 | HLA-A | LCK | PGR | CCR10 | CXCL9
Other Diseases
Granular Corneal Dystrophy | Granular Corneal Dystrophy Type 1 | Granuloma Annulare | Graves Disease | Gray Platelet Syndrome | Greenberg Dysplasia | Greig Cephalopolysyndactyly Syndrome | Growth Hormone Excess | Guanidinoacetate Methyltransferase Deficiency | Guillain-Barre Syndrome | Guttate Psoriasis | Gynecomastia | Gyrate Atrophy Of The Choroid And Retina | H Syndrome | Haim-Munk Syndrome | Hairy Cell Leukemia | Hamartoma | HANAC Syndrome | Hartnup Disease | Hartsfield Syndrome | Hashimoto Thyroiditis | Headache | Heart Block | Heart Failure | Heart Septal Defects | Heavy Chain Disease | Heimler Syndrome | HELLP Syndrome | Hemangioblastoma | Hemangioendothelioma | Hemangioma | Hemimegalencephaly | Hemochromatosis | Hemochromatosis Type 1 | Hemochromatosis Type 2 | Hemoglobinopathies | Hemolytic Anemia | Hemolytic Uremic Syndrome | Hemolytic Uremic Syndrome, Atypical | Hemophagocytic Lymphohistiocytosis | Hemophilia | Hemorrhage | Hemorrhagic Disorders | Hemorrhoids | Hemosiderosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Hepatic Adenomatosis | Hepatic Steatosis | Hepatic Veno-occlusive Disease | Hepatitis | Hepatitis A | Hepatitis B, Chronic | Hepatitis C, Chronic | Hepatitis D | Hepatitis E | Hepatitis, Alcoholic | Hepatitis, Autoimmune | Hepatitis, Chronic | Hepatoblastoma | Hepatopulmonary Syndrome | Hepatorenal Syndrome | Hereditary Coproporphyria | Hereditary Elliptocytosis | Hereditary Folate Malabsorption | Hereditary Hemorrhagic Telangiectasia | Hereditary Hemorrhagic Telangiectasia Type 2 | Hereditary Mixed Polyposis Syndrome | Hereditary Multiple Exostoses | Hereditary Neuropathy With Liability To Pressure Palsies | Hereditary Pyropoikilocytosis | Hereditary Sensory And Autonomic Neuropathy | Hereditary Sensory Neuropathy Type 1 | Hereditary Spastic Paraplegia | Hereditary Spherocytosis | Hereditary Xerocytosis | Hermansky-Pudlak Syndrome | Hernia, Inguinal | Herpes Genitalis | Herpes Simplex Dermatitis | Heterotopic Ossification | HIBCH Deficiency | Hidradenitis | Hidradenitis Suppurativa | High Molecular Weight Kininogen Deficiency | Histiocytic Sarcoma | Histiocytosis | Hodgkin Lymphoma | Holoprosencephaly | Holt-Oram Syndrome | Homocystinuria | Hoyeraal-Hreidarsson Syndrome | Huntington's Disease | Huntington's Disease-like 2 | HUPRA Syndrome | Hydrocephalus | Hydrocephalus, Normal Pressure | Hydrolethalus Syndrome | Hydronephrosis | Hydrops Fetalis | Hyper IgE Syndrome | Hyperacusis | Hyperammonemia | Hyperandrogenemia | Hyperbilirubinemia, Neonatal | Hypercalcemia | Hypercalciuria | Hypercholesterolemia | Hypercholesterolemia, Familial | Hyperekplexia | Hypereosinophilic Syndrome | Hyperferritinemia-cataract Syndrome | Hyperglycemia | Hyperhomocysteinemia | Hyperinsulinemia | Hyperinsulinemic Hypoglycemia | Hyperinsulinism-hyperammonemia Syndrome | Hyperkeratosis | Hyperlipidemia | Hyperlipidemia Type V | Hyperlipidemia, Familial Combined | Hypermethioninemia | Hypermetropia | Hyperostosis | Hyperoxaluria | Hyperparathyroidism | Hyperparathyroidism, Primary | Hyperparathyroidism, Secondary | Hyperparathyroidism-jaw Tumor Syndrome | Hyperphenylalaninemia | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hyperprolactinemia | Hypersensitivity | Hypersensitivity Pneumonitis | Hypersomnia | Hypertelorism | Hypertension | Hypertension, Essential | Hypertension, Portal | Hypertension, Pulmonary | Hypertension, Renal | Hypertension, Renovascular | Hypertensive Nephropathy | Hypertensive Retinopathy | Hyperthermia, Malignant | Hyperthyroidism | Hypertriglyceridemia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hypertrophy | Hyperuricemia | Hyperuricemic Nephropathy, Familial Juvenile | Hypervalinemia | Hypoalbuminemia | Hypobetalipoproteinemias | Hypocalcemia | Hypodontia | Hypoglycemia | Hypogonadism | Hypohidrotic Ectodermal Dysplasia | Hypohidrotic Ectodermal Dysplasia, X-linked | Hypokalemia | Hypokalemic Periodic Paralysis | Hypolipoproteinemia | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Hypoparathyroidism | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hypopigmentation | Hypopituitarism | Hypoplastic Left Heart Syndrome | Hypoproteinemia, Hypercatabolic | Hypospadias | Hypotension, Orthostatic | Hypothyroidism | Hypotonia-cystinuria Syndrome | Hypotrichosis | Hypotrichosis Simplex | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | ICF Syndrome | Ichthyosis | Ichthyosis Bullosa Of Siemens | Ichthyosis Hystrix, Curth-Macklin Type | Ichthyosis, X-linked | Idiopathic Multicentric Castleman Disease | Idiopathic Pulmonary Fibrosis | IgA Deficiency | IgA Nephropathy | Ileitis | IMAGe Syndrome | Imerslund-Grasbeck Syndrome | Immunoproliferative Disorders | Impetigo | Impulse Control Disorder | Inborn Errors Of Metabolism | Incontinentia Pigmenti | Infantile Liver Failure Syndrome 1 | Infantile Nephropathic Cystinosis | Infantile Neuroaxonal Dystrophy | Infantile Refsum Disease | Infantile Spasm | Infectious Diarrhea | Infertility | Infertility, Male | Inflammatory Bowel Disease | Inflammatory Joint Disease | Inflammatory Linear Verrucous Epidermal Nevus | Inflammatory Myofibroblastic Tumor | Inflammatory Myopathy | Influenza | Insulin Resistance | Insulinoma | Intellectual Disability, Autosomal Dominant 5 | Intermittent Claudication | Intermittent Explosive Disorder | Interstitial Lung Diseases | Intestinal Hypomagnesemia 1 | Intestinal Obstruction | Intestinal Pseudo-obstruction | Intestinal Tuberculosis | Intracerebral Hemorrhage | Intracranial Hypertension | Iron Deficiency Anemia | Iron Metabolism Disorders | Iron Overload | Irritable Bowel Syndrome | Ischemia | Isobutyryl-CoA Dehydrogenase Deficiency | Isovaleric Acidemia | Jacobsen Syndrome | Jalili Syndrome | Japanese Encephalitis | Jaundice, Obstructive | Jawad Syndrome | Johanson-Blizzard Syndrome | Joubert Syndrome | Joubert Syndrome 2 | Juvenile Hyaline Fibromatosis | Juvenile Myelomonocytic Leukemia | Juvenile Myoclonic Epilepsy | Juvenile Polyposis | Juvenile Xanthogranuloma | Kabuki Syndrome | Kabuki Syndrome 2 | Kallmann Syndrome | Kaposi Sarcoma | Kaposiform Hemangioendothelioma | Kashin-Beck Disease | Kawasaki Disease | KBG Syndrome | Kearns-Sayre Syndrome | Keloid | Keratitis | Keratitis-ichthyosis-deafness Syndrome | Keratoacanthoma | Keratoconjunctivitis | Keratoconus | Keratocystic Odontogenic Tumor | Keratopathy | Keratosis | Keratosis, Actinic | Keratosis, Seborrheic | Kernicterus | Kidney Stones | Kindler Syndrome | Kleine-Levin Syndrome | Klinefelter Syndrome | Klippel-Feil Syndrome | Knobloch Syndrome | Kohlschutter-Tonz Syndrome | Krabbe Disease | L-2-Hydroxyglutaric Aciduria | Lactose Intolerance | Lafora Disease | Lamellar Ichthyosis | Language Disorders | Large Granular Lymphocytic Leukemia | Larsen Syndrome | Lassa Fever | Lateral Meningocele Syndrome | Lathosterolosis | Lattice Corneal Dystrophy | Lattice Corneal Dystrophy Type 1 | Learning Disability | Leber Congenital Amaurosis | Leber Hereditary Optic Neuropathy | Left Ventricular Noncompaction | Leiomyoma | Leiomyosarcoma | Leishmaniasis, Cutaneous | Leishmaniasis, Visceral | Lennox-Gastaut Syndrome | Lentigo | LEOPARD Syndrome | Leprosy | Leri Pleonosteosis | Leri-Weill Dyschondrosteosis | Lesch-Nyhan Syndrome | Leukemia | Leukemia-lymphoma, Adult T-cell | Leukocyte Adhesion Deficiency | Leukocyte Adhesion Deficiency Type 1 | Leukodystrophies | Leukoencephalopathy, Progressive Multifocal | Leukoplakia | Leukoplakia, Oral | Lewy Body Dementia | Li-Fraumeni Syndrome | Lichen Planus | Lichen Sclerosus | Liddle Syndrome | Liebenberg Syndrome | Light Chain Amyloidosis | Ligneous Conjunctivitis | Limb Girdle Muscular Dystrophy | Lipid Metabolism Disorders | Lipid Storage Diseases | Lipid Storage Myopathy | Lipodystrophy | Lipoma | Lissencephaly 2 | Liver Diseases | Liver Failure | Liver Failure, Acute Infantile | LMNA-related Congenital Muscular Dystrophy | Localized Scleroderma | Loeys-Dietz Syndrome | Loeys-Dietz Syndrome Type 4 | Long QT Syndrome Type 1 | Long QT Syndrome Type 2 | Long QT Syndrome Type 3 | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Low Phospholipid Associated Cholelithiasis | Low Tension Glaucoma | LRBA Deficiency | Lung Diseases | Lupus Erythematosus | Lyme Disease | Lymphangioleiomyomatosis | Lymphangioma | Lymphangiomatosis | Lymphedema | Lymphedema-distichiasis Syndrome | Lymphoma | Lymphoma Lymphoblastic | Lymphoma, AIDS-related | Lymphoma, B-cell | Lymphoma, Follicular | Lymphoma, Mantle Cell | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Lymphomatoid Granulomatosis | Lymphoproliferative Disease, X-linked | Lymphoproliferative Disorders | Lysosomal Acid Lipase Deficiency | Mabry Syndrome | Macrodactyly | Macrophage Activation Syndrome | Macrophagic Myofasciitis | Macular Corneal Dystrophy | Macular Corneal Dystrophy Type 1 | Macular Degeneration | Majeed Syndrome | Major Depression | Malaria | Malaria, Cerebral | Malignant Fibrous Histiocytoma | Malignant Peripheral Nerve Sheath Tumor | Malnutrition | Malonyl-CoA Decarboxylase Deficiency | Mandibuloacral Dysplasia With Type A Lipodystrophy | Mannosidase Deficiency Diseases | Maple Syrup Urine Disease | Marfan Syndrome | Marinesco-Sjogren Syndrome | Marshall-Smith Syndrome | Martsolf Syndrome | Mast Cell Leukemia | Mastitis | Maternally Inherited Diabetes And Deafness | McCune-Albright Syndrome | McKusick Type Metaphyseal Chondrodysplasia | McLeod Syndrome | Measles | Meckel-Gruber Syndrome | Meconium Ileus | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Medulloblastoma | Meesmann Corneal Dystrophy | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Megalencephaly | Megaloblastic Anemia | Meier-Gorlin Syndrome | Melanocytic Nevus | Melanoma | Melanoma, Malignant | Melanoma, Uveal | MELAS Syndrome | Meleda Disease | Melnick-Needles Syndrome | Membranous Nephropathy | Meniere's Disease | Meningeal Melanocytoma
