Glioblastoma Multiforme
About the Disease
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology
Common Targets / Biomarkers
G5777 | G7515 | G7525 | G6714 | G11186 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G3055 | G1499 | G84636 | G3684 | P6747 | G4353 | G2668 | G6790 | P16165 | G472 | G25 | G83596 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | G1956 | G2268 | G5144 | G6326 | G4486 | G3576 | G3717 | G9748 | P5575 | CDK4/Cyclin D1 | G407007 | G4194 | G137196 | G9578 | G3949 | G1806 | G7170 | G1160 | G7705 | G5198 | P12956 | G2936 | G3021 | G3133 | G3672 | G222166 | G9467 | G3309 | G2191 | P16092 | Carbonic Anhydrase (nonspecified subtype) | G4648 | G222171 | G9590 | G6774 | G260293 | Kainate Receptor (GluR) (nonspecified subtype) | G7015 | G7098 | G54970 | P6176 | G3000 | G1445 | G7057 | G4192 | G2335 | Tyrosine-Protein Kinases Src (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | G201243 | G204801 | G120892 | G695 | G10013 | G3077 | G4267 | G3066 | P18508 | G3598 | G149998 | G5311 | G55869 | G6608 | G4199 | G3620 | P5755 | Heat shock protein 90 (nonspecified subtype) | G246100 | G5142 | Cyclin-dependent kinase (nonspecified subtype) | G6595 | G10419 | G8883 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | G59272 | G595 | G3091 | G648 | G7376 | Thioredoxin-disulfide reductase (TrxR) (nonspecified subtype) | G1815 | G1991 | G1021 | G3752 | G7431 | Thyroid hormone receptor (nonspecified subtype) | G406903 | G407011 | G8140 | G546 | G1464 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | G1269 | P6058 | G54981 | G558 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G219527 | G22909 | Hedgehog Protein (nonspecified subtype) | Ephrin Receptor (nonspecified subtype) | G759 | P11019 | HER (erbB) (nonspecified subtype) | Ribonucleoside-diphosphate reductase | G3371 | G55107 | G3932 | G660 | G771 | G801 | G51564 | G10280 | G1236 | G6319 | G1432 | P8262 | G5133 | G5600 | G598 | G6446 | G1436 | G102724428 | Calcium channel (nonspecified subtype) | G10062 | G11012 | G3815 | G1950 | G27436 | G4015 | G1457 | G1019 | Heat Shock Protein 27 (Hsp27) (nonspecified subtype) | G7295 | G217 | G10320 | P12327 | G2357 | G8784 | G1030 | G29126 | G1723 | G5728 | G3566 | G7150 | G3417 | G4780 | CDK9/Cyclin T1 | G6334 | G6386 | G7852 | G5395 | G8698 | G6708 | G10460 | Fibroblast growth factor (FGF) (nonspecified subtype) | G145781 | G2013 | G9817 | G4921 | G5291 | G9493 | G613 | G79054 | G5295 | G66002 | G406952 | G23476 | G2022 | G1191 | G383 | G8518 | G5460 | G1785 | G5293 | G27284 | G3035 | G6355 | G144811 | DNA Topoisomerase II (nonspecified subtype) | G23187 | G331 | G1813 | G2261 | G5209 | Chloride channel (nonspecified subtype) | G401563 | G7465 | G1025 | G9732 | G1268 | Raf kinase (nonspecified subtype) | G673 | G2015 | G8841 | G6098 | P5561 | G1490 | G100048912 | G10630 | P5762 | G6490 | G1859 | G7514 | Chaperone (nonspecified subtype) | G3689 | G51393 | G55872 | G1029 | G4440 | G5159 | G285 | P5756 | G142 | G8444 | G22914 | G11155 | G3916 | G406991 | G2313 | G10399 | G3065 | G283731 | G904 | G2719 | G4016 | G4170 | Tyrosine Kinase (nonspecified subtype) | P16126 | G2042 | G7442 | G10215 | G5727 | STAT5 (nonspecified subtype) | G2202 | G100499483 | G5837 | G7046 | G1180 | G6358 | G5468 | G57101 | G1278 | G64478 | G1051 | G64211 | G144132 | G9021 | G3105 | P10959 | G1638 | P40594 | G79836 | G182 | G706 | G9429 | G8462 | P16964 | G2475 | G9788 | G25937 | G970 | G597 | G6597 | G5002 | Interferon (nonspecified subtype) | G7517 | Pyruvate dehydrogenase kinase (nonspecified subtype) | G7097 | G6387 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G51750 | G26136 | G10461 | G105376244 | G57007 | G3990 | G1016 | sigma Receptor (nonspecified subtype) | G2324 | G3480 | G2051 | G896 | P12328 | G4035 | G22918 | G2346 | G9263 | G5536 | G494551 | G3832 | G83987 | G10312 | G3418 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G28996 | G3170 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G6405 | G23028 | G2321 | G2444 | G1182 | G5888 | G7157 | ADP/ATP Translocase (nonspecified subtype) | Sodium channel (nonspecified subtype) | G3939 | G7301 | G80325 | G2913 | G640 | G4318 | G2260 | G79660 | G100528032 | Dopamine receptor (nonspecified subtype) | G4017 | G283987 | G5915 | G5315 | G599 | G8842 | G1116 | G5894 | P33717 | G2194 | G23235 | G56912 | G780 | G976 | G1195 | G7010 | G1969 | L-Type calcium channel (nonspecified subtype) | G5292 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G2081 | G5579 | G4193 | Cannabinoid receptor (nonspecified subtype) | G84171 | G8019 | G80380 | G760 | G9149 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | P6884 | G5618 | G356 | G768 | G9365 | G1485 | G4481 | G6335 | G4067 | G7293 | G137835 | G57585 | G84868 | G9031 | G8476 | G5328 | G154 | G5228 | G55768 | G150094 | G4313 | G84695 | Notch receptor (nonspecified subtype) | Focal Adhesion Kinases (FAK) (nonspecified subtype) | G3991 | G1786 | G2066 | CDK6/Cyclin D3 | G54106 | G54890 | G10371 | G10855 | G4036 | G1493 | P6348 | G5743 | G6236 | G4763 | G3082 | G1508 | G284 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | G4233 | G7490 | G5290 | G4056 | G81571 | G10038 | G961 | G355 | G4843 | G4907 | G107 | G58190 | G177 | G7124 | G57519 | P5678 | G367 | G2064 | G5598 | G1234 | G390992 | G799 | G2322 | G91828 | G4070 | G213 | G8445 | G2534 | G26280 | G1728 | G4363 | G4613 | G8989 | G684 | G4323 | G22809 | G332 | G358 | G79068 | G1293 | G6515 | G5156 | G340061 | G7132 | G390113 | P5759 | G5916 | G56135 | P13024 | G5979 | Potassium Channels (nonspecified subtype) | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | P16740 | G7153 | G7428 | G4255 | G5243 | G1196 | Histone deacetylase (nonspecified subtype) | G220 | G1814 | G7294 | G240 | G5329 | G54567 | G100533107 | G4100 | G2247 | G930 | P16091 | G80381 | G91300 | G384 | G9388 | G1129 | G3781 | alpha-Mannosidase (nonspecified subtype) | G1588 | G2034 | G100124700 | G238 | G84804 | G5538 | G1890 | G8767 | G6470 | G2950 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G596 | G64077 | G5347 | G54361 | G9290 | G2956 | G64434 | G51185 | G327 | G7048 | G114548 | CDK4/Cyclin D3 | Protein Phosphatase (nonspecified subtype) | G3791 | G5294 | G10413 | G3176 | G4312 | G2130
Other Diseases
Glioma | Gliosarcoma | Globozoospermia | Glomerulonephritis | Glomerulonephritis, Membranoproliferative | Glomerulonephritis, Membranous | Glucagonoma | GLUT1 Deficiency Syndrome | Glutaric Aciduria Type 1 | Glutaric Aciduria Type 2 | Glutaric Aciduria Type 3 | Glutathione Synthetase Deficiency | Glycogen Storage Disease | Glycogen Storage Disease Type 0 | Glycogen Storage Disease Type 0, Muscle | Glycogen Storage Disease Type 1 | Glycogen Storage Disease Type 1a | Glycogen Storage Disease Type 1b | Glycogen Storage Disease Type 3 | Glycogen Storage Disease Type 4 | Glycogen Storage Disease Type 5 | Glycogen Storage Disease Type 6 | Glycogen Storage Disease Type 9 | GM2-gangliosidosis AB Variant | Gnathodiaphyseal Dysplasia | GNE Myopathy | Goiter | Goldenhar Syndrome | Gout | Graft-versus-host Disease | Granular Corneal Dystrophy | Granular Corneal Dystrophy Type 1 | Granuloma Annulare | Graves Disease | Gray Platelet Syndrome | Greenberg Dysplasia | Greig Cephalopolysyndactyly Syndrome | Growth Hormone Excess | Guanidinoacetate Methyltransferase Deficiency | Guillain-Barre Syndrome | Guttate Psoriasis | Gynecomastia | Gyrate Atrophy Of The Choroid And Retina | H Syndrome | Haim-Munk Syndrome | Hairy Cell Leukemia | Hamartoma | HANAC Syndrome | Hartnup Disease | Hartsfield Syndrome | Hashimoto Thyroiditis | Headache | Heart Block | Heart Failure | Heart Septal Defects | Heavy Chain Disease | Heimler Syndrome | HELLP Syndrome | Hemangioblastoma | Hemangioendothelioma | Hemangioma | Hemimegalencephaly | Hemochromatosis | Hemochromatosis Type 1 | Hemochromatosis Type 2 | Hemoglobinopathies | Hemolytic Anemia | Hemolytic Uremic Syndrome | Hemolytic Uremic Syndrome, Atypical | Hemophagocytic Lymphohistiocytosis | Hemophilia | Hemorrhage | Hemorrhagic Disorders | Hemorrhoids | Hemosiderosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Hepatic Adenomatosis | Hepatic Steatosis | Hepatic Veno-occlusive Disease | Hepatitis | Hepatitis A | Hepatitis B, Chronic | Hepatitis C, Chronic | Hepatitis D | Hepatitis E | Hepatitis, Alcoholic | Hepatitis, Autoimmune | Hepatitis, Chronic | Hepatoblastoma | Hepatopulmonary Syndrome | Hepatorenal Syndrome | Hereditary Coproporphyria | Hereditary Elliptocytosis | Hereditary Folate Malabsorption | Hereditary Hemorrhagic Telangiectasia | Hereditary Hemorrhagic Telangiectasia Type 2 | Hereditary Mixed Polyposis Syndrome | Hereditary Multiple Exostoses | Hereditary Neuropathy With Liability To Pressure Palsies | Hereditary Pyropoikilocytosis | Hereditary Sensory And Autonomic Neuropathy | Hereditary Sensory Neuropathy Type 1 | Hereditary Spastic Paraplegia | Hereditary Spherocytosis | Hereditary Xerocytosis | Hermansky-Pudlak Syndrome | Hernia, Inguinal | Herpes Genitalis | Herpes Simplex Dermatitis | Heterotopic Ossification | HIBCH Deficiency | Hidradenitis | Hidradenitis Suppurativa | High Molecular Weight Kininogen Deficiency | Histiocytic Sarcoma | Histiocytosis | Hodgkin Lymphoma | Holoprosencephaly | Holt-Oram Syndrome | Homocystinuria | Hoyeraal-Hreidarsson Syndrome | Huntington's Disease | Huntington's Disease-like 2 | HUPRA Syndrome | Hydrocephalus | Hydrocephalus, Normal Pressure | Hydrolethalus Syndrome | Hydronephrosis | Hydrops Fetalis | Hyper IgE Syndrome | Hyperacusis | Hyperammonemia | Hyperandrogenemia | Hyperbilirubinemia, Neonatal | Hypercalcemia | Hypercalciuria | Hypercholesterolemia | Hypercholesterolemia, Familial | Hyperekplexia | Hypereosinophilic Syndrome | Hyperferritinemia-cataract Syndrome | Hyperglycemia | Hyperhomocysteinemia | Hyperinsulinemia | Hyperinsulinemic Hypoglycemia | Hyperinsulinism-hyperammonemia Syndrome | Hyperkeratosis | Hyperlipidemia | Hyperlipidemia Type V | Hyperlipidemia, Familial Combined | Hypermethioninemia | Hypermetropia | Hyperostosis | Hyperoxaluria | Hyperparathyroidism | Hyperparathyroidism, Primary | Hyperparathyroidism, Secondary | Hyperparathyroidism-jaw Tumor Syndrome | Hyperphenylalaninemia | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hyperprolactinemia | Hypersensitivity | Hypersensitivity Pneumonitis | Hypersomnia | Hypertelorism | Hypertension | Hypertension, Essential | Hypertension, Portal | Hypertension, Pulmonary | Hypertension, Renal | Hypertension, Renovascular | Hypertensive Nephropathy | Hypertensive Retinopathy | Hyperthermia, Malignant | Hyperthyroidism | Hypertriglyceridemia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hypertrophy | Hyperuricemia | Hyperuricemic Nephropathy, Familial Juvenile | Hypervalinemia | Hypoalbuminemia | Hypobetalipoproteinemias | Hypocalcemia | Hypodontia | Hypoglycemia | Hypogonadism | Hypohidrotic Ectodermal Dysplasia | Hypohidrotic Ectodermal Dysplasia, X-linked | Hypokalemia | Hypokalemic Periodic Paralysis | Hypolipoproteinemia | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Hypoparathyroidism | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hypopigmentation | Hypopituitarism | Hypoplastic Left Heart Syndrome | Hypoproteinemia, Hypercatabolic | Hypospadias | Hypotension, Orthostatic | Hypothyroidism | Hypotonia-cystinuria Syndrome | Hypotrichosis | Hypotrichosis Simplex | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | ICF Syndrome | Ichthyosis | Ichthyosis Bullosa Of Siemens | Ichthyosis Hystrix, Curth-Macklin Type | Ichthyosis, X-linked | Idiopathic Multicentric Castleman Disease | Idiopathic Pulmonary Fibrosis | IgA Deficiency | IgA Nephropathy | Ileitis | IMAGe Syndrome | Imerslund-Grasbeck Syndrome | Immunoproliferative Disorders | Impetigo | Impulse Control Disorder | Inborn Errors Of Metabolism | Incontinentia Pigmenti | Infantile Liver Failure Syndrome 1 | Infantile Nephropathic Cystinosis | Infantile Neuroaxonal Dystrophy | Infantile Refsum Disease | Infantile Spasm | Infectious Diarrhea | Infertility | Infertility, Male | Inflammatory Bowel Disease | Inflammatory Joint Disease | Inflammatory Linear Verrucous Epidermal Nevus | Inflammatory Myofibroblastic Tumor | Inflammatory Myopathy | Influenza | Insulin Resistance | Insulinoma | Intellectual Disability, Autosomal Dominant 5 | Intermittent Claudication | Intermittent Explosive Disorder | Interstitial Lung Diseases | Intestinal Hypomagnesemia 1 | Intestinal Obstruction | Intestinal Pseudo-obstruction | Intestinal Tuberculosis | Intracerebral Hemorrhage | Intracranial Hypertension | Iron Deficiency Anemia | Iron Metabolism Disorders | Iron Overload | Irritable Bowel Syndrome | Ischemia | Isobutyryl-CoA Dehydrogenase Deficiency | Isovaleric Acidemia | Jacobsen Syndrome | Jalili Syndrome | Japanese Encephalitis | Jaundice, Obstructive | Jawad Syndrome | Johanson-Blizzard Syndrome | Joubert Syndrome | Joubert Syndrome 2 | Juvenile Hyaline Fibromatosis | Juvenile Myelomonocytic Leukemia | Juvenile Myoclonic Epilepsy | Juvenile Polyposis | Juvenile Xanthogranuloma | Kabuki Syndrome | Kabuki Syndrome 2 | Kallmann Syndrome | Kaposi Sarcoma | Kaposiform Hemangioendothelioma | Kashin-Beck Disease | Kawasaki Disease | KBG Syndrome | Kearns-Sayre Syndrome | Keloid | Keratitis | Keratitis-ichthyosis-deafness Syndrome | Keratoacanthoma | Keratoconjunctivitis | Keratoconus | Keratocystic Odontogenic Tumor | Keratopathy | Keratosis | Keratosis, Actinic | Keratosis, Seborrheic | Kernicterus | Kidney Stones | Kindler Syndrome | Kleine-Levin Syndrome | Klinefelter Syndrome | Klippel-Feil Syndrome | Knobloch Syndrome | Kohlschutter-Tonz Syndrome | Krabbe Disease | L-2-Hydroxyglutaric Aciduria | Lactose Intolerance | Lafora Disease | Lamellar Ichthyosis | Language Disorders | Large Granular Lymphocytic Leukemia | Larsen Syndrome | Lassa Fever | Lateral Meningocele Syndrome | Lathosterolosis | Lattice Corneal Dystrophy | Lattice Corneal Dystrophy Type 1 | Learning Disability | Leber Congenital Amaurosis | Leber Hereditary Optic Neuropathy | Left Ventricular Noncompaction | Leiomyoma | Leiomyosarcoma | Leishmaniasis, Cutaneous | Leishmaniasis, Visceral | Lennox-Gastaut Syndrome | Lentigo | LEOPARD Syndrome | Leprosy | Leri Pleonosteosis | Leri-Weill Dyschondrosteosis | Lesch-Nyhan Syndrome | Leukemia | Leukemia-lymphoma, Adult T-cell | Leukocyte Adhesion Deficiency | Leukocyte Adhesion Deficiency Type 1 | Leukodystrophies | Leukoencephalopathy, Progressive Multifocal | Leukoplakia | Leukoplakia, Oral | Lewy Body Dementia | Li-Fraumeni Syndrome | Lichen Planus | Lichen Sclerosus | Liddle Syndrome | Liebenberg Syndrome | Light Chain Amyloidosis | Ligneous Conjunctivitis | Limb Girdle Muscular Dystrophy | Lipid Metabolism Disorders | Lipid Storage Diseases | Lipid Storage Myopathy | Lipodystrophy | Lipoma | Lissencephaly 2 | Liver Diseases | Liver Failure | Liver Failure, Acute Infantile | LMNA-related Congenital Muscular Dystrophy | Localized Scleroderma | Loeys-Dietz Syndrome | Loeys-Dietz Syndrome Type 4 | Long QT Syndrome Type 1 | Long QT Syndrome Type 2 | Long QT Syndrome Type 3 | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Low Phospholipid Associated Cholelithiasis | Low Tension Glaucoma | LRBA Deficiency | Lung Diseases | Lupus Erythematosus | Lyme Disease | Lymphangioleiomyomatosis | Lymphangioma | Lymphangiomatosis | Lymphedema | Lymphedema-distichiasis Syndrome | Lymphoma | Lymphoma Lymphoblastic | Lymphoma, AIDS-related | Lymphoma, B-cell | Lymphoma, Follicular | Lymphoma, Mantle Cell | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Lymphomatoid Granulomatosis | Lymphoproliferative Disease, X-linked | Lymphoproliferative Disorders | Lysosomal Acid Lipase Deficiency | Mabry Syndrome | Macrodactyly | Macrophage Activation Syndrome | Macrophagic Myofasciitis | Macular Corneal Dystrophy | Macular Corneal Dystrophy Type 1 | Macular Degeneration | Majeed Syndrome | Major Depression | Malaria | Malaria, Cerebral | Malignant Fibrous Histiocytoma | Malignant Peripheral Nerve Sheath Tumor | Malnutrition | Malonyl-CoA Decarboxylase Deficiency | Mandibuloacral Dysplasia With Type A Lipodystrophy | Mannosidase Deficiency Diseases | Maple Syrup Urine Disease
