Open-angle Glaucoma
About the Disease
Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to glaucoma 1, open angle, a and exfoliation syndrome. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Extracellular matrix organization and Burn wound healing. The drugs Tobramycin and Polymyxin B have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and endothelial, and related phenotypes are nervous system and homeostasis/metabolism
Common Targets / Biomarkers
CYP19A1 | MRPS21 | LOC102723944 | Proteasome Complex | MED12 | TNF | GPR55 | Complement component 1q | GDNF | PDIA5 | TP53AIP1 | PNPT1 | MMP1 | FMO4 | CARHSP1 | LOC105370504 | COL12A1 | PMM2 | EEIG1 | LOC102724137 | CHEK2 | CAT | ITIH1 | DST | SOD1 | LINC01948 | LINC02542 | LOC107986636 | SLC1A3 | ACTA2 | EDNRA | XRCC1 | MEGF11 | KLRD1 | SNCA | MFF-DT | FAUP4 | IL37 | ADAMTS6 | SCN7A | VGLL4 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | IFNB1 | KDR | ADAMTS10 | PREP | Carbonic Anhydrase (nonspecified subtype) | BDNF | ZNRD2 | FMNL2 | FBN1 | SMG6 | MADD | NT5DC3 | ATRNL1 | COL8A2 | CTNNA3 | ABI3BP | IL1B | GLIS3 | LRRK2 | VAV2 | SYNE2 | CYP2D6 | LOC100506532 | ADAMTS8 | CADM2 | GLT8D2 | PWAR1 | SHMT2 | TERT | NR3C2 | PRKCG | COL1A1 | TXNRD2 | IDO1 | SEC14L2 | ACIN1 | OAS3 | LRRK1 | LPAR1 | CA6 | DLG5 | PTPRF | ROCK1 | KIDINS220 | NTM | HMGA2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | AKT1 | MYOC | EPDR1 | NAGK | CA12 | CNR2 | LPP | MIR3196 | MRPL9 | CYTB | RAMP2 | RPGRIP1 | RERE | CARD10 | TJP1 | LOC105377927 | CPAMD8 | CDKN2B | MMP12 | SIX6 | AGBL1 | TLR4 | BICC1 | LOC100130331 | LOC145845 | GDF7 | CASC20 | ZP4 | ADORA1 | NF-kappaB (NFkB) | TMCO1-AS1 | LOC105374007 | CWC27 | TMEM119 | ESR2 | SLC4A10 | COL5A1 | alpha-Adrenoceptor (nonspecified subtype) | SLC6A2 | PRKAG2 | C10orf53 | E2F6 | DNMBP | CA13 | GCM1 | LOXL1-AS1 | SMARCC2 | PTPRJ | CA7 | KANK1 | TMTC2 | DNAH6 | TOP1P1 | DGCR8 | FERMT2 | OR6C75 | ABCA1 | ARID5B | ANKRD18CP | PLCE1 | DDX20 | MAPT | CNR1 | MIR182 | MTNR1B | CDKN2B-AS1 | Uncharacterized LOC102724761 | ARHGEF12 | CNN2 | GAS7 | OPTN | cAMP-Dependent protein kinase (PKA) | VSX2 | NDUFAF6 | DYRK1A | DIRC3 | SOD2 | LOXL1 | ARVCF | BIRC6 | SLC23A2 | LOC105376196 | LOC105378189 | EFEMP1 | CDKN2A | SLC23A1 | BAX | Reverse transcriptase (Telomerase) | B4GALT3 | MGC27382 | K(ATP) Channel (nonspecified subtype) | ADORA2A | MMP7 | ATOH7 | CAV1 | LMX1B | LINC02640 | TNR | F2 | LINC00886 | LTBP1 | PHKG1 | SRBD1 | ACVR1 | LMX1B-DT | ADRB1 | ERMN | RBP1 | PTGS1 | AFAP1 | RAN | SOD3 | TIMP1 | TNS1 | DGKD | XPO5 | beta-Adrenoceptor (nonspecified subtype) | ANGPTL7 | LTBP2 | TMCO1 | LINC01322 | TLR2 | ACOXL | WDR36 | ANTXR1 | VPS45 | BMP6 | ND4 | OLR1 | ANKH | F5 | LOC105372130 | TRIOBP | LOXL2 | LOC107984782 | PTPRB | ASB10 | ADAMTS17 | RARB | ESR1 | OMG | DCLK1 | COL6A2 | TMEM181 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | TGFB2 | PDE7B | GPR158 | FASN | Adrenoceptor (nonspecified subtype) | AGBL2 | APEX1 | BNIP1 | GPX4 | PTGER1 | LOC730100 | HSPA12A | LOC105378780 | PAX6 | GMDS | AP-1 Transcription Factor Complex | COCH | SIK2 | GP6 | TEK | MMP9 | WNT10A | BCAS3 | FBXO32 | IL1A | SLC5A1 | CA2 | DST-AS1 | LY86-AS1 | COL4A3 | FLNB | NOS3 | ADAMTS2 | STON2 | LOC105374860 | ROCK2 | TP53 | ADPRS | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | PKP4 | FASLG | COL11A1 | DGKB | OPA1 | GUCY2C | CAV2 | ANGPT1 | LINC01641 | HIVEP3 | SMAD3 | LOC102723323 | AGTR2 | HPSE2 | APP | FNDC3B | LOC105370108 | NF1 | CFH | ASTN2 | EXOC2 | TTPA | ABO | RIPK3 | MMP2 | KIF26A | RREB1 | AQP1 | FOXC1 | MYRF | PKN2 | COL6A3 | LOC107986141 | GALC | PITX1 | LOC107986142 | CYP1B1 | TBK1 | PTGFR | ABCC4 | Rho kinase (ROCK) (nonspecified subtype) | CDH23 | Potassium Channels (nonspecified subtype) | NR2F1-AS1 | IKBKE | CYP46A1 | THSD7A | NTF4 | LINC02692 | TAP2 | APOE | VAV3 | RAPSN | ATXN2 | COX1 | ENOX2 | ZNF664-RFLNA | EXOC4 | CNTNAP4 | LINC02322 | Soluble guanylyl cyclase | LOC107986440 | ZNRD2-DT | PTGER2 | LHPP | MTHFR | RUNX2-AS1 | PDZD2 | PABPC1L | OSBP2
Other Diseases
Ophthalmia, Sympathetic | Ophthalmoplegia | Opisthorchiasis | Optic Nerve Diseases | Optic Nerve Hypoplasia, Bilateral | Optic Neuropathy | Optic Neuropathy, Anterior Ischemic | Oral Lichen Planus | Ornithine Transcarbamylase Deficiency | Orotic Aciduria | Orthostatic Intolerance | Osmotic Demyelination Syndrome | Osteitis | Osteoarthritis | Osteochondroma | Osteochondrosis | Osteogenesis Imperfecta | Osteogenesis Imperfecta Type II | Osteogenesis Imperfecta Type III | Osteogenesis Imperfecta Type IV | Osteogenesis Imperfecta Type V | Osteogenesis Imperfecta Type VI | Osteoglophonic Dysplasia | Osteomalacia | Osteomyelitis | Osteonecrosis | Osteonecrosis Of The Jaw | Osteopathia Striata With Cranial Sclerosis | Osteopetrosis | Osteoporosis | Osteoporosis, Postmenopausal | Osteoporosis-pseudoglioma Syndrome | Osteosarcoma | Osteosclerosis | Otitis Externa | Otitis Media | Otopalatodigital Syndrome Type 2 | Otosclerosis | Ovarian Hyperstimulation Syndrome | Ovarian Sex Cord-stromal Tumor | Overactive Bladder | Pachyonychia Congenita | Paget's Disease Of The Breast | Pain | Palmoplantar Keratoderma | Palsy, Cerebral | Pancreatitis | Pancreatitis, Chronic | Pancytopenia | Panic Disorder | Panniculitis | Pantothenate Kinase-associated Neurodegeneration | Panuveitis | Papilledema | Papilloma | Papillon-Lefevre Syndrome | Papillorenal Syndrome | Papulopustular Rosacea | Paraganglioma | Paraplegia | Parapsoriasis | Parkinson Disease 6, Autosomal Recessive Early-onset | Parkinson's Disease | Parkinsonism | Paronychia | Paroxysmal Kinesigenic Dyskinesia | Paroxysmal Nocturnal Hemoglobinuria | Partington Syndrome | Parvovirus B19 Infection | PASLI Disease | Patent Ductus Arteriosus | Patent Foramen Ovale | Paternal Uniparental Disomy Of Chromosome 14 | Pathological Gambling | Pearson Syndrome | Peeling Skin Syndrome Type B | Peeling Skin Syndrome, Acral Type | Pelizaeus-Merzbacher Disease | Pelvic Inflammatory Disease | Pemphigoid | Pemphigus | Pemphigus Foliaceus | Pemphigus Vulgaris | Pendred Syndrome | Pericarditis | Periodic Limb Movement Disorder | Periodontitis | Peripheral Neuropathy | Peripheral T-cell Lymphoma | Peritonitis | Perivascular Epithelioid Cell Tumor | Periventricular Leukomalacia | Periventricular Nodular Heterotopia | Pernicious Anemia | Peroxisomal Disorder | Persistent Fetal Circulation | Persistent Hyperplastic Primary Vitreous | Persistent Mullerian Duct Syndrome | Persistent Truncus Arteriosus | Personality Disorders | Peters-plus Syndrome | Peutz-Jeghers Syndrome | Peyronie's Disease | Pfeiffer Syndrome | PHARC Syndrome | Phenylketonuria | Phenylketonuria II | Pheochromocytoma | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Phosphoglycerate Dehydrogenase Deficiency | Photosensitivity | Pierpont Syndrome | Pierre Robin Syndrome | Pierson Syndrome | Pigment Dispersion Syndrome | Pilomatrix Carcinoma | Pineoblastoma | Pitt-Hopkins Syndrome | Pituitary Disorders | Pituitary Dwarfism | Pituitary Stalk Interruption Syndrome | Placenta Previa | Plasma Cell Dyscrasia | Plasma Cell Leukemia | Plasmacytoma | Platelet Disorders | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Pleomorphic Xanthoastrocytoma | Pleural Tuberculosis | Pleurisy | Pneumococcal Meningitis | Pneumoconiosis | Pneumonia, Bacterial | Pneumonia, Mycoplasma | Pneumonia, Viral | Pneumothorax | POEMS Syndrome | Poikiloderma With Neutropenia | Poirier-Bienvenu Neurodevelopmental Syndrome | Polyarteritis Nodosa | Polycystic Kidney, Autosomal Dominant | Polycystic Kidney, Autosomal Recessive | Polycystic Liver | Polycystic Ovary Syndrome | Polycythemia | Polycythemia Vera | Polydactyly | Polymicrogyria | Polymyalgia Rheumatica | Polymyositis | Polyneuropathy | Polyomavirus Nephropathy | Polyradiculopathy | Pompe Disease | Pontocerebellar Hypoplasia | Pontocerebellar Hypoplasia Type 2 | Porencephaly | Poretti-Boltshauser Syndrome | Porokeratosis | Porphyria | Porphyria Cutanea Tarda | Porphyria, Acute Intermittent | Porphyria, Variegate | Portal Vein Thrombosis | Postaxial Polydactyly | Posterior Polar Cataract | Postpartum Depression | Postpoliomyelitis Syndrome | Potocki-Shaffer Syndrome | Pouchitis | Prader-Willi Syndrome | Pre-eclampsia | Preaxial Polydactyly | Precocious Puberty | Prediabetes | Pregnancy, Ectopic | Premature Ejaculation | Premenstrual Syndrome | Presbycusis | Presbyopia | Priapism | Primary Aldosteronism | Primary Biliary Cholangitis | Primary Carnitine Deficiency | Primary Cutaneous Amyloidosis | Primary Erythromelalgia | Primary Familial Brain Calcification | Primary Hyperoxaluria | Primary Hyperoxaluria Type 1 | Primary Hyperoxaluria Type 3 | Primary Lateral Sclerosis | Primary Ovarian Insufficiency | Primary Pigmented Nodular Adrenocortical Disease | Primary Progressive Aphasia | Primary Progressive Nonfluent Aphasia | Primary Sclerosing Cholangitis | Primary Torsion Dystonia | Primrose Syndrome | Proctitis | Progressive Encephalopathy-optic Atrophy Syndrome | Progressive External Ophthalmoplegia | Progressive Familial Intrahepatic Cholestasis | Progressive Familial Intrahepatic Cholestasis Type 1 | Progressive Familial Intrahepatic Cholestasis Type 2 | Progressive Familial Intrahepatic Cholestasis Type 3 | Progressive Myoclonic Epilepsy | Progressive Osseous Heteroplasia | Prolactinoma | Prolidase Deficiency | Prolymphocytic Leukemia | Proopiomelanocortin Deficiency | Prostatitis | Proteasome-associated Autoinflammatory Syndrome 2 | Protein C Deficiency | Protein S Deficiency | Proximal Symphalangism | Prune Belly Syndrome | Prurigo Nodularis | Pseudo-pseudohypoparathyroidism | Pseudoachondroplasia | Pseudoexfoliation Syndrome | Pseudohermaphroditism | Pseudohypoaldosteronism | Pseudohypoparathyroidism Type 1A | Pseudohypoparathyroidism Type 1B | Pseudohypoparathyroidism Type 1C | Pseudohypoparathyroidism Type 2 | Pseudomyxoma Peritonei | Psoriasis | Pterygium | Pulmonary Alveolar Microlithiasis | Pulmonary Alveolar Proteinosis | Pulmonary Capillary Hemangiomatosis | Pulmonary Sclerosing Hemangioma | Pulmonary Stenosis | Pulmonary Tuberculosis | Pulmonary Vein Stenosis | Pulmonary Veno-occlusive Disease | Pulverulent Zonular Cataract | Pupil Disorders | Pure Autonomic Failure | Pure Red Cell Aplasia | Purpura | Purpura, Thrombotic Thrombocytopenic | Pycnodysostosis | Pyelonephritis | Pyloric Stenosis, Infantile Hypertrophic | Pyoderma Gangrenosum | Pyruvate Carboxylase Deficiency Disease | Pyruvate Decarboxylase Deficiency | Pyruvate Dehydrogenase Deficiency | Pyruvate Kinase Deficiency | Raine Syndrome | Rash | Raynaud Phenomenon | Recurrent Respiratory Papillomatosis | Reflex Epilepsy | Relapsing Polychondritis | REM Sleep Behavior Disorder | Renal Dysplasia | Renal Failure | Renal Hypomagnesemia 3 | Renal Hypouricemia | Renal Medullary Carcinoma | Renal Oncocytoma | Renal Tubular Acidosis | Renal Tubular Dysgenesis | Renal-hepatic-pancreatic Dysplasia | Renpenning Syndrome | Restless Legs Syndrome | Restrictive Dermopathy | Reticular Dysgenesis | Retinal Coloboma | Retinal Degeneration | Retinal Detachment | Retinal Diseases | Retinal Dystrophy | Retinal Telangiectasia | Retinal Vasculitis | Retinitis | Retinitis Pigmentosa | Retinitis Pigmentosa 3 | Retinoblastoma | Retinopathy Of Prematurity | Retinopathy, Diabetic | Retinoschisis | Rett Syndrome | Reye Syndrome | Rhabdoid Tumor | Rhabdomyosarcoma | Rhabdomyosarcoma, Alveolar | Rhabdomyosarcoma, Embryonal | Rheumatic Heart Disease | Rheumatoid Arthritis | Rhinitis | Rhizomelic Chondrodysplasia Punctata | Riboflavin Transporter Deficiency Neuronopathy | Richter's Syndrome | Rickets | Rift Valley Fever | Roberts Syndrome | Robinow Syndrome | Rolandic Epilepsy | Rosacea | Rothmund-Thomson Syndrome | Rotor Syndrome | Rubeosis Iridis | Rubinstein-Taybi Syndrome | Saethre-Chotzen Syndrome | Salla Disease | Sandhoff Disease | SAPHO Syndrome | Sarcoidosis | Sarcoidosis, Pulmonary | Sarcoma | Sarcoma, Alveolar Soft Part | Sarcoma, Endometrial Stromal | Sarcoma, Ewing | Sarcomatoid Carcinoma Of The Lung | Sarcosinemia | Saul-Wilson Syndrome | Scabies | Scapuloperoneal Myopathy, X-linked Dominant | Scapuloperoneal Spinal Muscular Atrophy | Schaaf-Yang Syndrome | Schamberg Disease | Schindler Disease | Schistosomiasis | Schistosomiasis Mansoni | Schizencephaly | Schizophrenia | Schizotypal Personality Disorder | Schnitzler Syndrome | Schnyder Crystalline Corneal Dystrophy | Schuurs-Hoeijmakers Syndrome | Schwannoma | Schwannomatosis | Schwartz-Jampel-Aberfeld Syndrome | Scleritis | Sclerocornea | Scleroderma | Scleroderma, Diffuse | Sclerosing Cholangitis | Sclerosteosis | Sclerosteosis 2 | Scoliosis | Seasonal Mood Disorder | Seborrheic Dermatitis | Seizures | Seizures-scoliosis-macrocephaly Syndrome | Seminoma | Sengers Syndrome | Senior-Loken Syndrome | Sensorineural Hearing Loss | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Sensory Neuropathy | Sepiapterin Reductase Deficiency | Sertoli Cell-only Syndrome | Sezary Syndrome | Shock, Cardiogenic | Short-chain Acyl-CoA Dehydrogenase Deficiency | Shprintzen-Goldberg Syndrome | Shwachman-Bodian-Diamond Syndrome | Sialoadenitis | Sick Sinus Syndrome | Sick Sinus Syndrome 1 | Sickle Cell Anemia | Sickle Cell Disease | Silicosis | Silver-Russell Syndrome | Sitosterolemia | Situs Inversus | Sjogren Syndrome | Skin Carcinoma | Skin Fragility-woolly Hair Syndrome | Skin Papilloma | Sleep Apnea | Sleep Apnea, Central | Sleep Apnea, Obstructive | Sleep Disorder | Small Lymphocytic Lymphoma | Smith-Kingsmore Syndrome | Smith-Lemli-Opitz Syndrome | Smith-Magenis Syndrome | Smoldering Myeloma | Snyder-Robinson Syndrome | Sorsby Fundus Dystrophy | Sotos Syndrome | Spastic Paraplegia Type 7 | Spasticity | Specific Granule Deficiency | Speech Disorders | Spina Bifida | Spinal And Bulbar Muscular Atrophy | Spinal Cord Diseases | Spinal Muscular Atrophy | Spinal Muscular Atrophy Type 2 | Spinal Muscular Atrophy Type 3 | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Spinocerebellar Ataxia Type 1
