SARM1: A Potential Drug Target and Biomarker (G23098)

Target Name: SARM1

NCBI ID: G23098

SARM1: A Potential Drug Target and Biomarker

Sterile alpha motif domain-containing protein 2 (SARM1) is a protein that has been identified as a potential drug target and biomarker. SARM1 is a non-coding RNA molecule that is expressed in various tissues and organs, including the brain, heart, and kidneys. It is characterized by the presence of a sterile alpha motif, which is a specific type of non-coding RNA molecule that is known to play a role in the regulation of gene expression.

The discovery of SARM1 as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. For example, SARM1 has been shown to be involved in the regulation of cell proliferation, which could make it a potential target for drugs that are designed to inhibit cell proliferation. Additionally, SARM1 has been shown to play a role in the regulation of immune responses, which could make it a potential target for drugs that are designed to enhance or dampen the immune response.

Properties of SARM1

SARM1 is a non-coding RNA molecule that is characterized by the presence of a sterile alpha motif. The sterile alpha motif is a specific type of non-coding RNA molecule that is known to play a role in the regulation of gene expression. It is composed of four nucleotides: U, G, C, and A. The sterile alpha motif is able to bind to specific DNA sequences, which allows it to interact with other non-coding RNA molecules and proteins.

SARM1 is expressed in a variety of tissues and organs, including the brain, heart, and kidneys. It has been shown to be involved in the regulation of cell proliferation, stem cell maintenance, and immune responses.

Potential drug targets

SARM1 is a potential drug target because it is involved in the regulation of cell proliferation and immune responses. This makes it a potential target for drugs that are designed to inhibit cell proliferation or enhance the immune response. For example, SARM1 has been shown to play a role in the regulation of cell cycle progression, which could make it a potential target for drugs that are designed to inhibit the activity of the cell cycle regulator. Additionally, SARM1 has been shown to play a role in the regulation of immune responses, which could make it a potential target for drugs that are designed to enhance or dampen the immune response.

Biomarker

SARM1 has also been identified as a potential biomarker for a variety of diseases. For example, SARM1 has been shown to be involved in the regulation of cell proliferation, which could make it a potential biomarker for cancer. Additionally, SARM1 has been shown to play a role in the regulation of immune responses, which could make it a potential biomarker for autoimmune diseases.

Conclusion

Sterile alpha motif domain-containing protein 2 (SARM1) is a protein that has been identified as a potential drug target and biomarker. SARM1 is characterized by the presence of a sterile alpha motif, which is a specific type of non-coding RNA molecule that is known to play a role in the regulation of gene expression. It is expressed in various tissues and organs, including the brain, heart, and kidneys, and has been shown to be involved in the regulation of cell proliferation and immune responses. As a result, SARM1 is a potential target for drugs that are designed to inhibit cell proliferation or enhance the immune response. Additionally, SARM1 has also been identified as a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of SARM1 in the regulation of gene expression and immune responses.

Protein Name: Sterile Alpha And TIR Motif Containing 1

Functions: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262)

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