NACAD: A Protein Involved in Multiple Cellular Processes and Potential Drug Target

Target Name: NACAD

NCBI ID: G23148

Other Name(s): NAC-alpha domain-containing protein 1 | NAC alpha domain containing | KIAA0363 | NACAD_HUMAN

NACAD: A Protein Involved in Multiple Cellular Processes and Potential Drug Target

NACAD (NAC-alpha domain-containing protein 1) is a protein that is expressed in a variety of tissues and cells in the human body. It is a member of the NAC family of proteins, which are known for their ability to interact with and modulate the activity of nuclear factor kappa B (NF-kappa-B), a protein that plays a critical role in regulating cellular processes such as inflammation, cell survival, and metabolism.

One of the unique features of NACAD is its ability to interact with multiple NF-kappa-B subunits, including the N-terminal subunit and the C-terminal subunit. This interaction allows NACAD to modulate the activity of NF-kappa-B and influence a wide range of cellular processes, including inflammation, cell migration, and cell survival.

NACAD has also been shown to play a role in the regulation of cellular responses to various signaling pathways, including the TGF-β pathway. TGF-β is a critical signaling pathway that is involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation. NACAD has been shown to interact with the TGF-β receptor and regulate its activity.

In addition to its role in the regulation of NF-kappa-B and TGF-β signaling pathways, NACAD has also been shown to play a role in the regulation of cellular adhesion. Adhesion is the process by which cells stick together and form tissues. NACAD has been shown to interact with the adhesion molecule E-cadherin and regulate its activity. This interaction allows NACAD to influence the formation and maintenance of tight junctions, which are a type of cell-cell adhesion structure that is critical for the proper functioning of tissues and organs.

NACAD has also been shown to play a role in the regulation of cellular apoptosis, which is the process by which cells die and are removed from the body. NACAD has been shown to interact with the pro-apoptotic protein Bax and regulate its activity. This interaction allows NACAD to influence the formation and execution of programmed cell death, which is a critical part of the regulation of cellular life cycle.

In addition to its role in the regulation of cellular processes, NACAD has also been shown to play a role in the regulation of cellular signaling pathways. NACAD has been shown to interact with the protein PDGF-R2 and regulate its activity. This interaction allows NACAD to influence the formation and maintenance of tissues and organs, including blood vessels and bones.

NACAD has also been shown to play a role in the regulation of the immune response. NACAD has been shown to interact with the protein PDGF-R2 and regulate its activity. This interaction allows NACAD to influence the formation and maintenance of immune cells, including T cells and natural killer cells.

In conclusion, NACAD is a protein that plays a critical role in the regulation of a wide range of cellular processes, including inflammation, cell migration, cell survival, and the immune response. Its ability to interact with multiple NF-kappa-B subunits and regulate the activity of TGF-β and PDGF-R2 signaling pathways makes NACAD an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of NACAD in cellular processes and its potential as a drug target.

Protein Name: NAC Alpha Domain Containing

Functions: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)

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