NAT16: A Potential Drug Target for Immune, Inflammation and Cancer

Target Name: NAT16

NCBI ID: G375607

NAT16: A Potential Drug Target for Immune, Inflammation and Cancer

NAT16 (C7orf52) is a protein that is expressed in various tissues throughout the body. It is a key regulator of the immune response and has been identified as a potential drug target in the treatment of various diseases.

NAT16 is a 16-kDa nucleotide-binding oligomerization domain (NOD) protein that is expressed in a variety of tissues, including the liver, spleen, and blood cells. It is a key regulator of the immune response, specifically of the T cell response.

NAT16 plays a crucial role in the regulation of T cell development and activation. It is a negative regulator of the T cell receptor (TCR), which is responsible for recognizing and responding to antigens in the body.

NAT16 functions by binding to the extracellular domain of the TCR and preventing it from activating signaling pathways that would promote T cell proliferation. This interaction between NAT16 and TCR is critical for the regulation of T cell development and activation.

In addition to its role in T cell regulation, NAT16 has also been shown to play a key role in the regulation of inflammation. It is a negative regulator of the nuclear factor kappa B (NF-kappa-B), which is a protein that promotes inflammation.

NAT16 functions by binding to the nuclear factor kappa B receptor and preventing it from activating signaling pathways that would promote inflammation. This interaction between NAT16 and NF-kappa-B is critical for the regulation of inflammation.

NAT16 has also been shown to play a key role in the regulation of cellular signaling pathways that are involved in cancer. It is a negative regulator of the src/FAK signaling pathway, which is involved in the regulation of cell growth and survival.

NAT16 functions by binding to the src/FAK signaling pathway and preventing it from activating signaling pathways that would promote cell growth and survival. This interaction between NAT16 and src/FAK is critical for the regulation of cellular signaling pathways that are involved in cancer.

Despite its important role in the regulation of various biological processes, NAT16 has not yet been identified as a drug target. Further research is needed to better understand the mechanisms of NAT16's function and to identify potential drug targets.

In conclusion, NAT16 is a protein that is expressed in various tissues throughout the body and plays a crucial role in the regulation of the immune response, inflammation, and cellular signaling pathways. Further research is needed to better understand its function and to identify potential drug targets.

Protein Name: N-acetyltransferase 16 (putative)

Functions: Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown

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