NCAPG2: A Potential Drug Target and Biomarker for Neurodegenerative Disorders

Target Name: NCAPG2

NCBI ID: G54892

NCAPG2: A Potential Drug Target and Biomarker for Neurodegenerative Disorders

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are progressive disorders that affect the brain and nervous system. These conditions are characterized by the progressive loss of brain cells, leading to the accumulation of neurotransmitters and the formation of neuroinclusions. One of the key protein components of these diseases is the non-SMC condensin II complex subunit G2 (NCAPG2), which plays a crucial role in the regulation of cell survival and the maintenance of neuronal structure.

The NCAPG2 gene is a member of the condensin II gene family, which is known for its role in the regulation of cell growth, differentiation, and survival. The NCAPG2 gene has four splice variants, including transcript variant 1 (NCAPG2), which is the most abundant and well-studied variant.

NCAPG2 function and significance

NCAPG2 is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, and muscle. It is a key component of the non-SMC condensin II complex, which is a complex of proteins that play a central role in the regulation of cell survival and the maintenance of neuronal structure.

The non-SMC condensin II complex is composed of several subunits, including NCAPG2, NCAPG3, NCASF1, and NCASF2. These subunits interact with each other to form a complex that is involved in the regulation of cell survival, cell cycle progression, and the formation of neuroinclusions.

NCAPG2 is a key subunit of the non-SMC condensin II complex, as it plays a crucial role in the regulation of cell survival and the maintenance of neuronal structure. It is involved in the regulation of the G1/G2 checkpoint, which is a critical mechanism that regulates the cell cycle and ensures that cells divide only once.

In addition to its role in the regulation of cell survival, NCAPG2 is also involved in the regulation of neuronal structure and function. It is a critical protein for the maintenance of neuronal morphology and for the regulation of synaptic plasticity, which is the ability of the brain to learn and adapt.

NCAPG2 dysfunction and neurodegenerative diseases

The NCAPG2 gene is the most well-studied gene in the non-SMC condensin II complex, and its dysfunction has been implicated in a number of neurodegenerative diseases.

Studies have shown that individuals with the NCAPG2 gene mutation are at increased risk for the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These mutations can alter the structure and function of NCAPG2, leading to the regulation of cell survival and the formation of neuroinclusions.

In addition to its role in the development of neurodegenerative diseases, NCAPG2 dysfunction has also been implicated in a number of other conditions, including cancer, fibrosis, and neuropsychiatric disorders.

The potential implications of targeting NCAPG2

The NCAPG2 gene is a promising drug target for the treatment of neurodegenerative diseases. By targeting NCAPG2, researchers may be able to disrupt the regulation of cell survival and the formation of neuroinclusions, leading to the therapeutic treatment of these conditions.

One approach to targeting NCAPG2 is through the use of small molecules that can modulate the activity of the NCAPG2 enzyme. These small molecules can interact with NCAPG2 to alter its structure and function, leading to the disruption of the NCAPG2-mediated regulation of cell survival and the formation of

Protein Name: Non-SMC Condensin II Complex Subunit G2

Functions: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis

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