NDC80: A Drug Target and Biomarker for Various Diseases (G10403)

Target Name: NDC80

NCBI ID: G10403

NDC80: A Drug Target and Biomarker for Various Diseases

NDC80 (KNTC2) is a drug target and a biomarker that is being studied for its potential utility in treating various diseases, including cancer. NDC80 is a non-coding RNA molecule that has been shown to play a role in the regulation of cell growth and has been linked to the development and progression of various diseases.

One of the key features of NDC80 is its ability to interact with a protein called p53, which is a well-known tumor suppressor protein. NDC80 has been shown to physically interact with p53 and can modulate its activity, leading to the regulation of cell growth and the development of cancer.

In addition to its role in cancer development, NDC80 has also been shown to have potential as a therapeutic target for other diseases. For example, NDC80 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's, and has been linked to the regulation of neurotransmitter synthesis and function.

NDC80 has also been shown to be involved in the regulation of inflammation and has potential as a therapeutic target for diseases such as rheumatoid arthritis and inflammatory bowel disease.

In conclusion, NDC80 is a promising drug target and biomarker that has the potential to revolutionize the treatment of a wide range of diseases. Further research is needed to fully understand the role of NDC80 in disease and to develop safe and effective treatments.

Protein Name: NDC80 Kinetochore Complex Component

Functions: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108)

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