Understanding The Potential Role of NEDD4L in Disease Treatment

Target Name: NEDD4L

NCBI ID: G23327

Understanding The Potential Role of NEDD4L in Disease Treatment

NEDD4L, or NEDD4-like protein 4, is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. NEDD4L is a protein that is expressed in many different tissues throughout the body, including the brain, and is involved in a number of cellular processes that are important for normal function.

One of the key functions of NEDD4L is its role in the regulation of mitochondrial function. Mitochondria are organelles that are responsible for generating the energy that cells need for their basic life functions, and they are also involved in the production of a number of signaling molecules that regulate the passage of information within cells. NEDD4L is involved in the regulation of these processes by helping to ensure that the mitochondria are properly organized and that they are able to function properly.

In addition to its role in mitochondrial function, NEDD4L is also involved in the regulation of a number of other cellular processes that are important for normal development and function. For example, NEDD4L is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. It is also involved in the regulation of cell signaling, which is the process by which cells communicate with one another to carry out a variety of tasks.

Given its involvement in so many important cellular processes, it is not surprising that NEDD4L has been identified as a potential drug target or biomarker for a wide range of diseases. For example, NEDD4L has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and it is also potential target for cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key challenges in studying NEDD4L as a potential drug target or biomarker is its complex structure and the difficulty of predicting how it will interact with specific molecules. However, researchers are making progress in understanding the role of NEDD4L in these processes and are working to develop new techniques for studying it.

In addition to its potential as a drug target or biomarker, NEDD4L is also of interest to researchers because of its potential role in the development of personalized medicine. As the field of personalized medicine continues to grow, researchers are looking for ways to use NEDD4L and other proteins to develop treatments that are tailored to the specific needs of individual patients.

Overall, NEDD4L is a complex and fascinating protein that is involved in a number of important cellular processes. As research continues to progress, it is likely to emerge as a promising drug target or biomarker for a wide range of diseases.

Protein Name: NEDD4 Like E3 Ubiquitin Protein Ligase

Functions: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:31959741, PubMed:33608556, PubMed:20064473). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556)

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