Understanding NEK4: Potential Drug Target Or Biomarker (G6787)

Target Name: NEK4

NCBI ID: G6787

Understanding NEK4: Potential Drug Target Or Biomarker

NEK4, or serine/threonine-protein kinase Nek4 variant 2, is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell growth, differentiation, and survival, and is involved in the development and progression of many diseases. Despite its importance, little is known about NEK4, and it has not been thoroughly studied. However, there is some interest in using it as a drug target or biomarker, due to its potential role in the treatment of certain diseases.

The Nek4 protein is a member of the Nek family of proteins, which are known for their role in cell signaling. The Nek4 protein is involved in the regulation of several cellular processes, including cell growth, differentiation, and survival. It is a key regulator of the cell cycle, and is involved in the G1/S transition, which is a critical step in the cell cycle that leads to the entry of the cell into the S phase.

NEK4 is also involved in the regulation of cell adhesion and migration. It is a critical regulator of the adherens junction, which is a structure that forms the boundary between cells and is involved in cell migration. It is also involved in the regulation of tight junctions, which are structures that allow cells to communicate with each other.

In addition to its role in cell signaling, NEK4 is also involved in the regulation of cellular stress. It is a key regulator of the DNA damage response, which is the cellular response to DNA damage. It is involved in the repair of DNA damage and in the regulation of cell cycle progression.

Despite its importance, little is known about NEK4. There are only a few studies that have explored its role in cell signaling and cellular processes. These studies have shown that NEK4 is involved in the regulation of cell growth, differentiation, and survival. They have also shown that it is involved in the regulation of cell adhesion and migration, as well as the regulation of cellular stress.

There is some interest in using NEK4 as a drug target or biomarker, due to its potential role in the treatment of certain diseases. For example, NEK4 has been shown to be involved in the development and progression of certain diseases, such as cancer. Additionally, it is thought to be involved in the regulation of cellular aging, which is a leading cause of death in humans.

In conclusion, NEK4 is a protein that is involved in several important cellular processes, including cell growth, differentiation, and survival. While more research is needed, there is some interest in using it as a drug target or biomarker, due to its potential role in the treatment of certain diseases. Further studies are needed to fully understand its role and potential applications in medicine.

Protein Name: NIMA Related Kinase 4

Functions: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage

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