Understanding The Potential Drug Targets of NFE2L3 (G9603)

Target Name: NFE2L3

NCBI ID: G9603

Understanding The Potential Drug Targets of NFE2L3

TheNot-So-Friendly-Folks (NSF) family of proteins plays a crucial role in various cellular processes, including cell signaling, DNA replication, and repair, and cellular maintenance. The NSF2 gene family is one of the most well-studied gene families in the NSF system, and its proteins have been implicated in a wide range of cellular processes, including cancer progression, neurodegenerative diseases, and developmental disorders. One of the NSF2 proteins that has garnered particular interest is NFE2L3 (NF2L3_HUMAN), a protein that has has been shown to interact with a variety of molecules and has been implicated in a number of cellular processes. In this article, we will explore the biology and potential drug targets of NFE2L3.

Structure and Expression

NFE2L3 is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, liver, and muscle. It is composed of a unique nucleotide-binding oligomerization (NBO) domain, a central transmembrane region, and a unique C -terminal region that is rich in conserved amino acid sequence. NFE2L3 has been shown to interact with a variety of molecules, including DNA, histones, and various signaling pathways, suggesting that it plays a critical role in cellular processes.

Function

NFE2L3 is involved in a number of cellular processes, including DNA replication, repair, and transcription. It has been shown to interact with the transcription factor TPP and to play a role in the regulation of gene expression. NFE2L3 has also been shown to be involved in the replication of damaged DNA, including in the repair of single-base substitutions and insertions.

In addition to its role in DNA replication and repair, NFE2L3 is also involved in the regulation of cellular signaling pathways. It has been shown to interact with a variety of signaling pathways, including the TGF-β pathway and the Wnt pathway. NFE2L3 has also has been shown to play a role in the regulation of cell adhesion, as well as in the regulation of cell migration and the development of cancer.

Potential Drug Targets

NFE2L3 is a potential drug target due to its involvement in a wide range of cellular processes. Its unique NBO domain and its ability to interact with a variety of molecules make it an attractive target for small molecules. In addition, its role in the regulation of DNA replication and repair, as well as its involvement in the regulation of cellular signaling pathways, suggest that it may be a useful target for drugs that target signaling pathways or that are involved in the regulation of DNA replication and repair.

Conclusion

In conclusion, NFE2L3 is a protein that has been shown to play a critical role in a wide range of cellular processes, including DNA replication, repair, and signaling pathways. Its unique NBO domain and its ability to interact with a variety of molecules make it an attractive target for small molecules. Further research is needed to fully understand the role of NFE2L3 in cellular processes and to develop effective drugs that target it.

Protein Name: NFE2 Like BZIP Transcription Factor 3

Functions: Activates erythroid-specific, globin gene expression

More Common Targets