NELL2: Potential Drug Target for Tissue Growth and Cancer Development

Target Name: NELL2

NCBI ID: G4753

NELL2: Potential Drug Target for Tissue Growth and Cancer Development

Neural epidermal growth factor-like 2 (NELL2) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and nails. It is a member of the epidermal growth factor (EGF) family, which includes EGF, EGFR, and PDGF, which are involved in cell proliferation and growth.

NELL2 has been shown to play a role in the development and maintenance of tissues that are dependent on rapid cell growth, such as the skin and hair. It has been shown to stimulate the production of new cells in the skin, hair, and nails, and to promote the growth of these cells.

In addition to its role in tissue growth, NELL2 has also been shown to play a role in the regulation of cell differentiation. It has been shown to promote the transition of stem cells into functional tissues, such as hair and skin cells, and to play a role in the development of cancer.

NELL2 is also a potential drug target for various diseases, including cancer, skin diseases, and autoimmune disorders.

One of the main advantages of NELL2 as a drug target is its ability to be targeted with small molecules. This is because its protein is produced by the body and is highly expressed in many tissues, making it an attractive target for small molecules that can be easily administered to the body.

Another advantage of NELL2 is its role in the regulation of cell growth and differentiation. This makes it an attractive target for drugs that are designed to promote cell growth or inhibit cell growth.

NELL2 has also been shown to play a role in the development of cancer. Studies have shown that NELL2 is highly expressed in various types of cancer, including skin cancer and breast cancer. Additionally, NELL2 has been shown to promote the growth of cancer cells, which suggests that it may play a role in the development of cancer.

In conclusion, NELL2 is a protein that has been shown to play a role in the development and maintenance of various tissues, including the skin and hair. It is also a potential drug target for various diseases, including cancer, skin diseases, and autoimmune disorders. Further research is needed to fully understand the role of NELL2 in these processes and to develop effective treatments.

Protein Name: Neural EGFL Like 2

Functions: Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)

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